Document Detail

Early postnatal dexamethasone therapy may lessen lung inflammation in premature infants with respiratory distress syndrome on mechanical ventilation.
MedLine Citation:
PMID:  9094727     Owner:  NLM     Status:  MEDLINE    
Early postnatal use of dexamethasone has recently been shown to be effective in improving the pulmonary status in premature infants with respiratory distress syndrome (RDS). To study the effect of dexamethasone on pulmonary inflammatory responses, we studied ten infants treated with dexamethasone and ten infants without this treatment. Serial tracheal aspirates were obtained for cell counts, neutrophil counts, total protein concentrations, and leukotriene B4 (LTB4) and 6-keto prostaglandin (PG)F(1 alpha) levels before and after starting the study. Infants in the dexamethasone-treated group required significantly lower mean airway pressures for ventilation and had lower PaCO2 values from day 3 to day 14 than infants in the control group, suggesting better pulmonary function. For infants in the dexamethasone group, the tracheal aspirates showed significantly lower cell and neutrophil counts, protein concentrations, and 6-keto-PGF(1 alpha) and LTB4 levels than in the control group. We conclude that early postnatal dexamethasone therapy may lessen lung inflammation and improve pulmonary function in infants with RDS.
J Y Wang; T F Yeh; Y J Lin; W Y Chen; C H Lin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  23     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-09     Completed Date:  1997-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
Department of Pediatrics, College of Medicine, National Cheng-Kung University, Tainan, Taiwan, R.O.C.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / analysis
Anti-Inflammatory Agents / therapeutic use*
Bronchoalveolar Lavage Fluid / chemistry,  cytology
Bronchopulmonary Dysplasia / prevention & control
Cell Count
Dexamethasone / therapeutic use*
Infant, Newborn
Infant, Premature
Leukotriene B4 / analysis
Respiration, Artificial*
Respiratory Distress Syndrome, Newborn / diagnosis,  therapy*
Time Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents; 50-02-2/Dexamethasone; 58962-34-8/6-Ketoprostaglandin F1 alpha; 71160-24-2/Leukotriene B4

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