| Early postnatal dexamethasone therapy may lessen lung inflammation in premature infants with respiratory distress syndrome on mechanical ventilation. | |
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MedLine Citation:
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PMID: 9094727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Early postnatal use of dexamethasone has recently been shown to be effective in improving the pulmonary status in premature infants with respiratory distress syndrome (RDS). To study the effect of dexamethasone on pulmonary inflammatory responses, we studied ten infants treated with dexamethasone and ten infants without this treatment. Serial tracheal aspirates were obtained for cell counts, neutrophil counts, total protein concentrations, and leukotriene B4 (LTB4) and 6-keto prostaglandin (PG)F(1 alpha) levels before and after starting the study. Infants in the dexamethasone-treated group required significantly lower mean airway pressures for ventilation and had lower PaCO2 values from day 3 to day 14 than infants in the control group, suggesting better pulmonary function. For infants in the dexamethasone group, the tracheal aspirates showed significantly lower cell and neutrophil counts, protein concentrations, and 6-keto-PGF(1 alpha) and LTB4 levels than in the control group. We conclude that early postnatal dexamethasone therapy may lessen lung inflammation and improve pulmonary function in infants with RDS. |
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Authors:
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J Y Wang; T F Yeh; Y J Lin; W Y Chen; C H Lin |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric pulmonology Volume: 23 ISSN: 8755-6863 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-06-09 Completed Date: 1997-06-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 193-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, College of Medicine, National Cheng-Kung University, Tainan, Taiwan, R.O.C. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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analysis Anti-Inflammatory Agents / therapeutic use* Bronchoalveolar Lavage Fluid / chemistry, cytology Bronchopulmonary Dysplasia / prevention & control Cell Count Dexamethasone / therapeutic use* Female Humans Infant, Newborn Infant, Premature Leukotriene B4 / analysis Male Respiration, Artificial* Respiratory Distress Syndrome, Newborn / diagnosis, therapy* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 50-02-2/Dexamethasone; 58962-34-8/6-Ketoprostaglandin F1 alpha; 71160-24-2/Leukotriene B4 |
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