Document Detail


Early postnatal changes of lipoprotein subclass profile in late preterm infants.
MedLine Citation:
PMID:  21963460     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Late preterm infants (LPIs; 34-37 gestational weeks at birth) have higher risk for several morbidities than do term infants (TIs). It has been suggested that a cholesterol and fatty acid supply may improve their outcomes. We investigated the lipoprotein subclass profile in LPIs to evaluate their early postnatal lipid metabolism. METHODS: Eighty-one infants (25 LPIs, 56 TIs) were included. Cholesterol and triglyceride (TG) concentrations in 12 lipoprotein subclasses were measured at birth and at 1month using HPLC. RESULTS: In LPIs, the cord blood exhibited higher cholesterol concentrations in medium and large subclasses of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) compared to the values in TIs. During the first month of life, LPIs had greater increases in cholesterol concentrations of medium and large subclasses of VLDL than TIs, whereas postnatal increases in cholesterol concentrations of medium and large subclasses of LDL and HDL were smaller. TG concentrations were not different in each VLDL subclass at birth and at 1month. CONCLUSIONS: In LPIs, cord blood lipoprotein subclass profiles and the early postnatal change exhibited different, especially in cholesterol concentrations.
Authors:
Nobuhiko Nagano; Tomoo Okada; Ryuta Yonezawa; Kayo Yoshikawa; Hidetoshi Fujita; Yukihiro Usukura; Masami Makimoto; Sigeharu Hosono; Yukihiko Fujita; Shigeru Takahashi; Hideo Mugishima; Tatsuo Yamamoto
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-22
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Department of Pediatrics and Child Health, Nihon University School of Medicine 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo173-8610, Japan.
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