Document Detail

Early postnatal blood pressure in preterm infants: effects of chorioamnionitis and timing of antenatal steroids.
MedLine Citation:
PMID:  19668111     Owner:  NLM     Status:  MEDLINE    
Previous studies suggest postnatal blood pressure in preterm infants to be decreased by chorioamnionitis and increased by antenatal steroids (AS). We examined the adjusted effects of both antenatal modulators on postnatal blood pressure (BP), with separate effects reported for histologic chorioamnionitis with or without fetal involvement and timing of AS. General characteristics, BP, and heart rate values during the first 72 h after birth were obtained from 271 infants with gestational age <or=32.0 wk. In unadjusted analyses, chorioamnionitis was associated with lower BP, most prominently so in infants with fetal involvement, without an effect on hypotension incidence. AS increased BP and decreased the incidence of hypotension when administered within 7 d before birth. In a multivariable mixed model analysis, the AS effect remained significant, whereas chorioamnionitis was not independently predictive of postnatal BP. Other variables associated with increased postnatal BP were gestational age and umbilical artery pH, whereas hemolysis, elevated liver enzymes, low platelets syndrome was associated with decreased BP. In conclusion, AS seem to increase postnatal BP and decrease hypotension in preterm infants when given within 7 d before birth. Conversely, chorioamnionitis did not significantly affect postnatal BP after multivariable adjustment.
Jasper V Been; Ren?? F Kornelisse; Ingrid G I J G Rours; Val??ria Lima Passos; Ronald R De Krijger; Luc J I Zimmermann
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  66     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-26     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  571-6     Citation Subset:  IM    
Department of Paediatrics, Maastricht University Medical Centre, Maastricht, The Netherlands.
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MeSH Terms
Blood Platelets / metabolism
Blood Pressure
Chorioamnionitis / physiopathology*
Gestational Age
Hemorrhage / metabolism
Hydrogen-Ion Concentration
Infant, Newborn
Infant, Premature
Liver / metabolism
Multivariate Analysis
Steroids / therapeutic use*
Umbilical Arteries / pathology
Reg. No./Substance:

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