Document Detail

Early postnatal behavior deficits after maternal carbon dioxide pneumoperitoneum during pregnancy.
MedLine Citation:
PMID:  12802645     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In this study, we tested the hypothesis that maternal pneumoperitoneum produces early postnatal behavior deficits in the offspring. METHODS: Time-dated pregnant guinea pigs were exposed to 45 min of carbon dioxide (CO2) pneumoperitoneum at a pressure of 7 mmHg. There was no manipulation of the control animals. On postnatal days (PND) 10 and 20, the behavior of their offspring was assessed by monitoring the locomotor activity of each of the pups in a 1 x 1 m chamber demarcated into 100 squares. Locomotor data was log-transformed and expressed as mean values (SD). RESULTS: At PND 10, pneumoperitoneum offspring exhibited significantly higher levels of locomotor activity than the offspring of controls (1.81 +/- 0.48 vs 1.33 +/- 0.78). The pneumoperitoneum pups continued to exhibit hyperactive behavior at PND 20 (1.83 +/- 0.72 vs 1.20 +/- 0.72). CONCLUSIONS: Maternal pneumoperitoneum produces postnatal hyperactivity in guinea pig offspring, suggesting that there may be long-term consequences associated with the physiologic changes produced in the fetus during CO2 insufflation.
S G de la Fuente; J Pinheiro; M Gupta; W S Eubanks; J D Reynolds
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Publication Detail:
Type:  Journal Article     Date:  2003-06-17
Journal Detail:
Title:  Surgical endoscopy     Volume:  17     ISSN:  1432-2218     ISO Abbreviation:  Surg Endosc     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2004-01-14     Completed Date:  2004-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806653     Medline TA:  Surg Endosc     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1823-5     Citation Subset:  IM    
Department of Surgery, Duke University Medical Center, Box 3479, Durham, NC 27710, USA.
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MeSH Terms
Animals, Newborn
Animals, Suckling
Birth Weight / drug effects
Carbon Dioxide / administration & dosage,  toxicity*
Fetus / drug effects*
Gestational Age
Guinea Pigs
Hyperkinesis / chemically induced*
Maternal-Fetal Exchange
Pneumoperitoneum, Artificial / adverse effects*
Prenatal Exposure Delayed Effects*
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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