Document Detail


Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia.
MedLine Citation:
PMID:  16428356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate whether postnatal allopurinol would reduce free radical induced reperfusion/reoxygenation injury of the brain in severely asphyxiated neonates. METHOD: In an interim analysis of a randomised, double blind, placebo controlled study, 32 severely asphyxiated infants were given allopurinol or a vehicle within four hours of birth. RESULTS: The analysis showed an unaltered (high) mortality and morbidity in the infants treated with allopurinol. CONCLUSION: Allopurinol treatment started postnatally was too late to reduce the early reperfusion induced free radical surge. Allopurinol administration to the fetus with (imminent) hypoxia via the mother during labour may be more effective in reducing free radical induced post-asphyxial brain damage.
Authors:
M J N L Benders; A F Bos; C M A Rademaker; M Rijken; H L Torrance; F Groenendaal; F van Bel
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-01-20
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  91     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-24     Completed Date:  2006-05-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F163-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center KE 4.123.1, PO Box 85090, 3508 AB Utrecht, the Netherlands. m.benders@azu.nl
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MeSH Terms
Descriptor/Qualifier:
Allopurinol / therapeutic use*
Asphyxia Neonatorum / drug therapy*
Brain Ischemia / etiology,  prevention & control*
Double-Blind Method
Free Radical Scavengers / therapeutic use*
Free Radicals / adverse effects
Humans
Infant, Newborn
Reperfusion Injury / etiology,  prevention & control*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Free Radical Scavengers; 0/Free Radicals; 315-30-0/Allopurinol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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