| Early post-operative hyperbaric oxygen therapy modifies neutrophile activation. | |
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MedLine Citation:
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PMID: 10430348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: To investigate the effect of acute hyperbaric oxygen therapy (HBOT) on post-operative sinusoidal endothelial cell (SEC) damage caused by activated neutrophils. METHODOLOGY: 12 non-cirrhotic patients (Group H), who underwent elective hepatectomy for liver cancer, were given 2 courses of HBOT: 2.0 atm with inhalation of 100% oxygen, for 60 min, at 3 hours and 24 hours after hepatectomy; they were then compared with the 12 patients (Group C) who had been treated to maintain normal hemodynamic values. RESULTS: In group H, peak levels of polymorphonuclear leukocyte elastase (PMNE) and thrombomodulin (TM) were clearly diminished and delayed compared to Group C. All subjects in Group C showed more than a 10% increase in CD18 12 hours after surgery; however, in Group H, the elevation of CD18 expression was clearly suppressed compared to Group C. No patient in Group H had post-operative hyperbilirubinemia or hepatic failure; however, 3 had post-operative hyperbilirubinemia and 1 had intraperitoneal infection in Group C. CONCLUSIONS: Our results provide direct evidence that HBOT, especially at 3 hours after hepatectomy, has favorable effects on the activation of neutrophiles decreasing SEC injury. |
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Authors:
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S Ueno; G Tanabe; K Kihara; D Aoki; K Arikawa; H Dogomori; T Aikou |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 46 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 1999 May-Jun |
Date Detail:
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Created Date: 1999-09-22 Completed Date: 1999-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: GREECE |
Other Details:
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Languages: eng Pagination: 1798-9 Citation Subset: IM |
Affiliation:
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First Department of Surgery, Kagoshima University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD18
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blood Endothelium, Vascular / immunology Hepatectomy* Humans Hyperbaric Oxygenation* Leukocyte Elastase / blood Liver / blood supply Liver Cirrhosis / surgery* Liver Neoplasms / surgery* Neutrophil Activation / immunology* Postoperative Care Postoperative Complications / immunology* Prognosis Prospective Studies Thrombomodulin / blood |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD18; 0/Thrombomodulin; EC 3.4.21.37/Leukocyte Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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