Document Detail


Early post-operative hyperbaric oxygen therapy modifies neutrophile activation.
MedLine Citation:
PMID:  10430348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: To investigate the effect of acute hyperbaric oxygen therapy (HBOT) on post-operative sinusoidal endothelial cell (SEC) damage caused by activated neutrophils. METHODOLOGY: 12 non-cirrhotic patients (Group H), who underwent elective hepatectomy for liver cancer, were given 2 courses of HBOT: 2.0 atm with inhalation of 100% oxygen, for 60 min, at 3 hours and 24 hours after hepatectomy; they were then compared with the 12 patients (Group C) who had been treated to maintain normal hemodynamic values. RESULTS: In group H, peak levels of polymorphonuclear leukocyte elastase (PMNE) and thrombomodulin (TM) were clearly diminished and delayed compared to Group C. All subjects in Group C showed more than a 10% increase in CD18 12 hours after surgery; however, in Group H, the elevation of CD18 expression was clearly suppressed compared to Group C. No patient in Group H had post-operative hyperbilirubinemia or hepatic failure; however, 3 had post-operative hyperbilirubinemia and 1 had intraperitoneal infection in Group C. CONCLUSIONS: Our results provide direct evidence that HBOT, especially at 3 hours after hepatectomy, has favorable effects on the activation of neutrophiles decreasing SEC injury.
Authors:
S Ueno; G Tanabe; K Kihara; D Aoki; K Arikawa; H Dogomori; T Aikou
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  46     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    1999 May-Jun
Date Detail:
Created Date:  1999-09-22     Completed Date:  1999-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1798-9     Citation Subset:  IM    
Affiliation:
First Department of Surgery, Kagoshima University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD18 / blood
Endothelium, Vascular / immunology
Hepatectomy*
Humans
Hyperbaric Oxygenation*
Leukocyte Elastase / blood
Liver / blood supply
Liver Cirrhosis / surgery*
Liver Neoplasms / surgery*
Neutrophil Activation / immunology*
Postoperative Care
Postoperative Complications / immunology*
Prognosis
Prospective Studies
Thrombomodulin / blood
Chemical
Reg. No./Substance:
0/Antigens, CD18; 0/Thrombomodulin; EC 3.4.21.37/Leukocyte Elastase

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