| Early post-injury exercise reverses memory deficits and retards the closed-head injury in mice. | |
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MedLine Citation:
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PMID: 23184513 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Closed-head injury (CHI) usually involves both physical damage of neurons and neuroinflammation. Although exercise promotes neuron repair and suppresses neuroinflammation, currently CHI patients often stay resting during the post-traumatic period. This study aimed to investigate whether and how post-injury exercise benefited the brain structure and function in CHI mice. CHI caused immediately elevated neurological severity score, rapid loss of object recognition memory, and followed by progressive location-dependent brain damages (neuronal loss and microglia activation in the cortex and hippocampus). An early exercise paradigm at moderate intensity (started 2 d post-impact and lasting for 7 or 14 days) effectively restored the object recognition memory, prevented the progressive neuronal loss and microglia activation. However, the exercise started 9 d post-impact was unable to recover recognition memory deficits. In parallel, early exercise intervention drastically promoted neurite regeneration, while late exercise intervention was much less effective. We further tested the possible involvement of brain-derived neurotrophic factor (BDNF) and MAP kinase phosphatase-1 (MKP-1) in the exercise-induced beneficial effects. Exercise gradually restored the impact-abolished hippocampal expression of BDNF and MPK-1, while oral administration of triptolide (a synthesis inhibitor of MKP-1 and an antagonist of nuclear factor-κB) before each bout of exercise blocked the exercise-restoring effects of MKP-1 and recognition memory, and the exercise-retarded neuronal loss. Although triptolide treatment alone inhibited microglia activation and maintained the neuron number, it did not recover the injury-hampered recognition memory. Taken together, moderate exercise shortly after CHI reversed the deficits in recognition memory and prevented the progression of brain injury. |
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Authors:
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Mei-Feng Chen; Tung-Yi Huang; Yu-Min Kuo; Lung Yu; Hsiun-Ing Chen; Chauying J Jen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-26 |
Journal Detail:
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Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Basic Medical Sciences, National Cheng Kung University; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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