Document Detail

Early pharmacological treatment of acute heart failure syndromes: a systematic review of clinical trials.
MedLine Citation:
PMID:  17453534     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Acute Heart Failure Syndromes (AHFS) is a common admission diagnosis associated with high mortality and hospital readmissions. Given the mixed results of recent clinical trials, the early management of AHFS remains controversial. OBJECTIVE: To review the recent evidence regarding current and investigational therapies for the early management of AHFS. DATA SOURCES: A systematic search of peer-reviewed publications was performed on MEDLINE and EMBASE from January 1990 to August 2006. The results of unpublished or ongoing trials were obtained from presentations at national and international meetings and pharmaceutical industry releases. Bibliographies from these references were also reviewed, as were additional articles identified by content experts. STUDY SELECTION AND DATA EXTRACTION: Criteria used for study selection were controlled study design, relevance to clinicians and validity based on venue of publication and power analysis. DATA SYNTHESIS: Although all current intravenous therapies for the early management of AHFS appear to improve hemodynamics, this may not always translate into short-term clinical benefit. CONCLUSION: The results of the trials conducted to date in AHFS have generally been disappointing. There is, therefore, an unmet need for new therapeutic approaches for the early management of AHFS that may improve the short-term and long-term outcomes.
Leonardo De Luca; Gregg C Fonarow; Alexandre Mebazaa; David D Shin; Sean P Collins; Karl Swedberg; Mihai Gheorghiade
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acute cardiac care     Volume:  9     ISSN:  1748-2941     ISO Abbreviation:  Acute Card Care     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-06-13     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101276603     Medline TA:  Acute Card Care     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  10-21     Citation Subset:  IM    
Division of Cardiology, European Hospital, Rome, Italy.
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MeSH Terms
Cardiac Output, Low / drug therapy*
Cardiovascular Agents / therapeutic use*
Clinical Trials as Topic*
Reg. No./Substance:
0/Cardiovascular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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