Document Detail


Early pathological changes in the cerebellum of patients with pure cerebellar syndrome demonstrated by diffusion-tensor imaging.
MedLine Citation:
PMID:  17035705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the early pathological changes in patients with sporadic cerebellar ataxia by measuring fractional anisotropy (FA) values in diffusion tensor MRIs (DTI). FA and apparent diffusion coefficient (ADC) values were compared in the brain stem and cerebellum of 5 patients with idiopathic cerebellar ataxia-C and 7 age-matched controls. Patients with sporadic cerebellar ataxia had decreased FA values in the bilateral cerebellar peduncle and cerebellar hemisphere, but normal FA values in the basis pontes. Assuming that the loss in FA parallels neuronal changes, our results suggest that the derangement and altered fiber integrity of the cerebellum are present regardless of the presence of morphological alterations on conventional MRI. Therefore, DTI may be superior to conventional MRI in the evaluation of early pathological changes in patients with sporadic cerebellar ataxia.
Authors:
Bora Yoon; Joong-Seok Kim; Kwang-Soo Lee; Bum-Soo Kim; So-Ryoung Chung; Yeong-In Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-11
Journal Detail:
Title:  European neurology     Volume:  56     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  166-71     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2006 S. Karger AG, Basel.
Affiliation:
Department of Neurology, Catholic University of Korea College of Medicine, Hangnam St. Mary's Hospital, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Mapping
Brain Stem / pathology
Cerebellar Ataxia / pathology*
Cerebellar Diseases / pathology*
Cerebellum / pathology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Reference Values

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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