Document Detail


Early oxidative stress in amniotic fluid of pregnancies with Down syndrome.
MedLine Citation:
PMID:  17208212     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Some evidence suggests that oxidative stress, due to an imbalance between oxidants and antioxidants, occurs in babies with Down syndrome (DS). This study tests the hypothesis that oxidative stress occurs early in DS pregnancies. DESIGN AND METHODS: Isoprostanes (IPs), a new marker of free radical-catalyzed lipid peroxidation, were measured in amniotic fluid from pregnancies with normal, growth restricted and DS fetuses, diagnosed by karyotype analysis of amniotic cells cultured. RESULTS: A nine-fold increase in IP concentrations was found in amniotic fluid of pregnancies with DS fetuses. This increase (595.15; 542.96-631.64 pg/ml, median; 95% CI), was greater than in pregnancies with fetal growth-restricted fetuses (155; 130.57-172.23 pg/ml, median; 95% CI) and normal fetuses (67; 49.82-98.38 pg/ml, median; 95% CI; p<0.0001). CONCLUSIONS: The study reveals that oxidative stress occurs early in pregnancy and supports the idea of testing whether prenatal antioxidant therapy may prevent or delay the onset of oxidative stress diseases in the DS population.
Authors:
S Perrone; M Longini; C V Bellieni; G Centini; A Kenanidis; L De Marco; F Petraglia; G Buonocore
Publication Detail:
Type:  Journal Article     Date:  2006-11-21
Journal Detail:
Title:  Clinical biochemistry     Volume:  40     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-23     Completed Date:  2007-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-80     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Policlinico Le Scotte, V.le Bracci 36, 53100 Siena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniotic Fluid / chemistry*
Biological Markers / analysis
Down Syndrome / diagnosis*
Female
Humans
Isoprostanes / analysis*
Oxidative Stress*
Pregnancy
Prenatal Diagnosis / methods*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Isoprostanes

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