| Early overanticoagulation with acenocoumarol due to a genetic polymorphism of cytochrome P450 CYP2C9. | |
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MedLine Citation:
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PMID: 14614357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the case of a young healthy woman who presented an early overanticoagulation when receiving acenocoumarol for a first thromboembolic episode. The patient had none of the risk factors known to influence the response to the coumarinic derivative except that she carried the rare *3 allelic variant of the cytochrome P450 CYP2C9 in a homozygous status. This case illustrates the role of the *3 polymorphism of the cytochrome P450 CYP2C9 as an independent risk factor modulating the sensitivity of patients to the anticoagulant effect of acenocoumarol. The usefulness of CYP2C9 genotyping before starting coumarinic treatments is discussed. |
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Authors:
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Elisabeth André-Kerneïs; Catherine Leroy-Matheron; Michèle Gouault-Heilmann |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 14 ISSN: 0957-5235 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-11-17 Completed Date: 2004-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: England |
Other Details:
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Languages: eng Pagination: 761-4 Citation Subset: IM |
Affiliation:
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Unité d'Hémostase de Thrombose, Service d'Hématologie Biologique, Centre Hospitalier Universitaire Henri Mondor, Créteil, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acenocoumarol
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adverse effects*,
therapeutic use Adult Anticoagulants / adverse effects*, therapeutic use Aryl Hydrocarbon Hydroxylases / genetics* Blood Coagulation Disorders / chemically induced*, enzymology, genetics Female Genotype Humans Polymorphism, Genetic* Risk Factors Thrombosis / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 152-72-7/Acenocoumarol; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/CYP2C9 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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