Document Detail

Early outcomes of thulium laser versus transurethral resection of the prostate for treating benign prostate hyperplasia: a systematic review and meta-analysis of comparative studies.
MedLine Citation:
PMID:  23980542     Owner:  NLM     Status:  Publisher    
Purpose: To assess the efficacy and safety of TmLRP versus TURP for treating with BPH. Methods: A systematic search of the electronic databases, including Medline, Scopus, CNKI and the Cochrane Library was performed up to May 1, 2013. The pooled outcomes of interest assessing the two techniques included demographic and clinical baseline characteristics, perioperative variables, complications and postoperative efficacy including maximum flow rate (Qmax), postvoid residual (PVR), quality of life (QoL) and International Prostate Symptom Score (IPSS). Results: Nine trials assessing TmLRP vs. TURP were considered suitable for meta-analysis including three RCT, two prospective and four retrospective studies. Compared with TURP, although TmLRP required a longer operating time (weighted mean difference [WMD]: 9.00 min; 95% confidence interval [CI], 2.53 to 15.47; p = 0.006), patients having TmLRP might benefit from significantly less seum sodium decreased (-3.58 mmol/l; 95% CI, -4.04 to -3.12; p < 0.001), less serum hemoglobin decrease (WMD: -0.94 mmol/l; 95% CI, -1.44to -0.44; p < 0.001), shorter time of catheterization (WMD: -2.07 d; 95% CI, -2.66 to -1.49; p < 0.001), shorter length of hospital stay (WMD: -1.87 d; 95% CI, -2.41 to -1.33; p < 0.001) and fewer total complications (odds ratio [OR]: 0.29; 95% CI, 0.20-0.41; p < 0.001). During the 1, 3, 6 and 12 months of postoperative follow-up, the procedures did not demonstrate a significant difference in Qmax, IPSS, PVR, and QoLS. Conclusions: Our data suggest that as a promising minimal invasive technique, TmLRP appears to be a safe, feasible and efficient alternative to TURP for treating BPH with reliable perioperative safety, fewer complications and comparable efficacy in relation to Qmax, PVR, QoL and IPSS. Because of the inherent limitations of the included studies, further large sample prospective, multi-centric, long-term follow-up studies and randomized control trials should be undertaken to confirm our findings.
Kun Tang; Zhengli Xu; Ding Xia; Xin Ma; Xiaolin Guo; Wei Guan; Zhiquan Hu; Xu Zhang; Zhangqun Ye; Hua Xu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-27
Journal Detail:
Title:  Journal of endourology / Endourological Society     Volume:  -     ISSN:  1557-900X     ISO Abbreviation:  J. Endourol.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807503     Medline TA:  J Endourol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Wuhan, China, 430030 ;
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