Document Detail


Early origins of obesity: programming the appetite regulatory system.
MedLine Citation:
PMID:  15705647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is evidence that changes in perinatal nutrition programme the development of relative fat mass and the regulation of appetite in adult life. These studies have been primarily in the rodent utilizing maternal overnutrition or undernutrition imposed at different stages of pregnancy and beyond, mapping of neuropeptide localization and activity and appropriate null mutant models. Whilst the rodent offers significant advantages in terms of a short gestation and the availability of useful transgenic and null mutant models, there are also advantages to using an animal model more akin to the human, in which all components of the 'fat-brain axis' are present before birth, such as the sheep. This review summarizes recent work on the expression and localization of the 'appetite regulatory' peptides in the fetal rodent and sheep hypothalamus and their potential role in the early programming of postnatal appetite and obesity.
Authors:
I Caroline McMillen; Clare L Adam; Beverly S Mühlhäusler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-02-10
Journal Detail:
Title:  The Journal of physiology     Volume:  565     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-18     Completed Date:  2005-08-16     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  9-17     Citation Subset:  IM    
Affiliation:
Discipline of Physiology, Centre for the Early Origins of Adult Health, School of Molecular and Biomedical Sciences, University of Adelaide, SA 5005, Australia. caroline.mcmillen@adelaide.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite*
Brain / embryology*,  physiopathology*
Cardiovascular System / embryology,  physiopathology
Diet
Energy Metabolism
Female
Humans
Maternal Exposure / adverse effects
Metabolic Syndrome X / embryology,  etiology,  physiopathology
Models, Biological
Obesity / embryology*,  etiology,  physiopathology*
Pregnancy
Prenatal Exposure Delayed Effects*
Prenatal Nutritional Physiological Phenomena*
Comments/Corrections
Comment In:
J Physiol. 2005 May 15;565(Pt 1):1   [PMID:  15790658 ]

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