| Early origins of heart disease: Low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy. | |
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MedLine Citation:
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PMID: 22774980 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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studies indicate that poor growth before birth is associated with left ventricular hypertrophy and an increased risk of death from heart disease later in life. In fetal life, the insulin-like growth factor (IGF) system has been implicated in physiological growth of the heart, while in postnatal life IGFs can be involved in both physiological and pathological cardiac hypertrophy. A reduction in substrate supply in fetal life, resulting in chronic hypoxaemia and intrauterine growth restriction, results in increased cardiac IGF-1R, IGF-2 and IGF-2R gene expression; and there is also evidence for a role of the IGF-2R in the ensuing cardiac hypertrophy. The persistent high level of cardiac IGF-2R gene expression from fetal to postnatal life may be due to epigenetic changes in key cardiac hypertrophy regulatory pathways. © 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd. |
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Authors:
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Kimberley C W Wang; Kimberley J Botting; Monalisa Padhee; Song Zhang; I Caroline McMillen; Catherine M Suter; Doug A Brooks; Janna L Morrison |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-7 |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: - ISSN: 1440-1681 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Early Origins of Adult Health Research Group, Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, 5001, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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