| Early oral feeding in acute pancreatitis: an alternative approach to tube feeding. Preliminary report. | |
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MedLine Citation:
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PMID: 16761474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Jejunal feeding is accepted in the treatment of severe acute pancreatitis (AP). Early oral feeding (EOF) is deemed to be detrimental in the early phase of AP. The aim of this study was to assess the safety and effectiveness of EOF in the treatment of AP. MATERIALS AND METHODS: 29 AP patients were prospectively enrolled within 1.96 days from the onset of disease. APACHE II score, SIRS, MODS, serum CRP and lipase were evaluated. All patients received EOF when gastro-enteric transit was not severely impaired. ICU, hospital stay and main outcomes were assessed. RESULTS: APACHE II score was > or = 8 in 10 patients at the admission ranging 0-13 points for the whole group. Alcohol (62%) and gallstones (38%) were the main etiologic factors. SIRS and MODS were diagnosed in 65% and pleural effusion in 24% of patients. EOF was started on average 3.27 days after admission providing 571 ml (280.0-1115.0 ml) of enteral formula daily for 10.38 days. Median lipase activity was 690 U/l (90-10175 U/l) and CRP concentration reached 91.25 mg/dL (3.5-210 mg/dL) before EOF. Progressive decrease of lipase activity and CRP concentration was observed during the EOF course, reaching median CRP 18.6 mg/L (4.6-96.7mg/L) by discharge. Two patients underwent surgical intervention. Minor side effects of EOF were successfully managed in 4 patients. No mortality was observed. CONCLUSION: EOF could be a safe and effective alternative of nutritional support in AP patients when gastro-enteric transit is not severely impaired. For better EOF assessment further clinical trials are required. |
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Authors:
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G Pupelis; K Snippe; H Plaudis; M Rudakovska |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Acta chirurgica Belgica Volume: 106 ISSN: 0001-5458 ISO Abbreviation: Acta Chir. Belg. Publication Date: 2006 Mar-Apr |
Date Detail:
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Created Date: 2006-06-09 Completed Date: 2006-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370571 Medline TA: Acta Chir Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 181-6 Citation Subset: IM |
Affiliation:
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Clinical Hospital "Gailezers", Department of Surgery, Riga, Latvia. pupelis@gailes.lv |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over C-Reactive Protein / metabolism Enteral Nutrition / methods* Feasibility Studies Female Humans Lipase / blood Male Middle Aged Pancreatitis / therapy* Pancreatitis, Acute Necrotizing / therapy Prospective Studies Safety Time Factors |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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