Document Detail


Early onset of syndrome of inappropriate antidiuretic hormone secretion (SIADH) after allogeneic haematopoietic stem cell transplantation: case report and review of the literature.
MedLine Citation:
PMID:  20515586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Severe hyponatraemia and syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a rare but fatal complication following stem cell transplantation (SCT). This case report details a patient with early-onset SIADH after allogeneic haematopoietic SCT (allo-HSCT) and reviews the literature on risk factors for the development of this condition. The patient, who had chronic myelogenous leukaemia, developed acute graft-versus-host disease (GVHD) on day 5 after allo-HSCT, which was relieved promptly by steroids. On day 18, he presented with hyponatraemia, which was refractory. Despite intensive restriction of fluid and administration of hypertonic saline, his condition worsened and he died of multiple systemic organ dysfunction. A review of the literature reveals that early-onset SIADH following SCT is insidious, but progresses rapidly. The severity of the disorder is underestimated because of the non-specific clinical features and the lack of effective treatment. Myeloablative conditioning and acute GVHD are two major important predisposing factors in SIADH.
Authors:
J Wei; Y Xiao; X Yu; J Zhou; Y Zhang
Related Documents :
2688416 - Case report and delineation of the congenital hypothalamic hamartoblastoma syndrome (pa...
12535046 - Popliteal pterygium syndrome with syngnathia.
17558836 - Conjunctival involvement in churg-strauss syndrome.
12534576 - The paroxysmal hemicrania-tic syndrome.
24962606 - Etanercept-associated transient bone marrow aplasia: a review of the literature and pat...
3755976 - Management of invasive frontoethmoidal sinus mucoceles.
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Journal of international medical research     Volume:  38     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  705-10     Citation Subset:  IM    
Affiliation:
Department of Haematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Fatal Outcome
Graft vs Host Disease / etiology
Hematopoietic Stem Cell Transplantation / adverse effects*
Humans
Inappropriate ADH Syndrome / etiology*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
Male
Transplantation, Homologous
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinicopathological features of solitary fibrous tumours in the extremities: four case reports and a...
Next Document:  Calponin expression in laryngeal myoepithelial carcinoma and its prognostic implications: a case rep...