| Early-onset schizophrenia is associated with impaired adolescent development of attentional capacity using the identical pairs continuous performance test. | |
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MedLine Citation:
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PMID: 16309895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors examined performance on the Continuous Performance Test-Identical Pairs "numbers" task in adolescents with schizophrenia (n=59) and healthy controls (n=55). Adjusting for an estimate of premorbid intelligence and socioeconomic status, patients performed worse than normal controls on all three d' conditions (2-digit, 3-digit, 4-digit). However, there was a significant group-by-age-by-condition interaction (F[4,100]=4.69, p<.01) indicating an interaction between development and disease state. At the simplest level of the task (2-digit) the difference between patients with schizophrenia and controls was evident at all ages; while for the more difficult levels of the task (3-digit, 4-digit), differences between groups gradually increased across the tested age span (10 to 20 years of age). Premorbid social isolation was associated with worse attentional performance in patients, suggesting a relationship and continuity with negative symptoms. These data suggest that attentional differences in adolescents with schizophrenia are better captured by different tasks at different ages. The discrepant findings of attentional impairments reported in the literature for adolescents with schizophrenia could reflect the underlying etiological complexity of the disorder that may have a variable impact on involved brain regions and neurocognitive functioning. |
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Authors:
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Emily Thaden; Joseph P Rhinewine; Todd Lencz; Hana Kester; Kelly L Cervellione; Inika Henderson; David Roofeh; Katherine E Burdick; Barbara Napolitano; Barbara A Cornblatt; Sanjiv Kumra |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2005-11-23 |
Journal Detail:
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Title: Schizophrenia research Volume: 81 ISSN: 0920-9964 ISO Abbreviation: Schizophr. Res. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-23 Completed Date: 2006-06-09 Revised Date: 2010-09-02 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 157-66 Citation Subset: IM |
Affiliation:
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The Zucker-Hillside Hospital, Department of Psychiatry Research 75-59 263rd Street, Glen Oaks, NY 11004, USA. ethaden@lij.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Attention Deficit Disorder with Hyperactivity / diagnosis*, psychology Child Developmental Disabilities / diagnosis*, psychology Female Humans Interview, Psychological Male Neuropsychological Tests / statistics & numerical data* Psychometrics / statistics & numerical data Psychotic Disorders / diagnosis*, psychology Reproducibility of Results Schizophrenia / diagnosis* Schizophrenic Psychology* |
| Grant Support | |
ID/Acronym/Agency:
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MH-60221/MH/NIMH NIH HHS; MH-64556/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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