Document Detail

Early-onset neutropenia is a risk factor for Candida colonization in very low-birth-weight neonates.
MedLine Citation:
PMID:  17178299     Owner:  NLM     Status:  MEDLINE    
Neutropenia is a major risk factor for bacterial colonization and sepsis in preterm neonates in the neonatal intensive care unit (NICU), but little is known about its relationships with candidal colonization (CC) in these settings. We performed a case-control study on neonates with birth weight of <1500 g admitted to our NICU during a 7-year period (1996-2003, N = 585). Through database search, infants with early-onset neutropenia (EON) (n = 68, group A) were identified and 1:1 matched with controls without EON (n = 68, group B). Microbiologic data from weekly surveillance cultures were examined to determine the presence and intensity of CC. Groups A and B were similar clinically and demographically. All group A neonates recovered from EON before the 8th day of life. Incidence of CC in the 1st month of life (at least 1 site) was significantly higher in group A (61.8% versus 35.3%, P = 0.002) and was not modified by treatment with recombinant granulocyte colony-stimulating factor. The same was true of CC intensity, expressed as the number of sites affected (P = 0.002). Incidence of candidal sepsis, mortality rates, and relative frequencies of the various subspecies of Candida among the isolates did not significantly differ between the 2 groups. In conclusion, EON in preterm neonates is a significant, independent risk factor for CC. Larger, prospective, adequately powered studies should verify whether increased CC related to neutropenia may translate into a similar increased occurrence of candidal sepsis in these settings.
Paolo Manzoni; Daniele Farina; Cesare Monetti; Claudio Priolo; MariaLisa Leonessa; Chiara Giovannozzi; Giovanna Gomirato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diagnostic microbiology and infectious disease     Volume:  57     ISSN:  0732-8893     ISO Abbreviation:  Diagn. Microbiol. Infect. Dis.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-20     Completed Date:  2007-07-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8305899     Medline TA:  Diagn Microbiol Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-83     Citation Subset:  IM    
Neonatology and Hospital NICU, Azienda Ospedaliera Regina Margherita - S.Anna. 10136 Torino, Italy.
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MeSH Terms
Candida / growth & development
Candidiasis* / epidemiology,  microbiology
Case-Control Studies
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases* / epidemiology,  microbiology
Infant, Very Low Birth Weight*
Intensive Care Units, Neonatal
Neutropenia / complications*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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