| Early-onset neonatal sepsis: cord blood cytokine levels at diagnosis and during treatment. | |
| | |
MedLine Citation:
|
PMID: 21085747 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess clinical and laboratory parameters and serum cytokine levels in 55 neonates who developed early-onset sepsis. METHODS: Clinical parameters associated with early-onset neonatal sepsis were assessed. White blood cell differential and serum C-reactive protein and glucose levels were measured upon diagnosis of sepsis and 48 hours later. IL-beta, IL-10, IL-6, and TNF-α levels were measured in cord blood samples obtained on the day of diagnosis and from samples collected 48 and 96 hours after treatment onset. RESULTS: Among newborns with early-onset sepsis, the length of hospital stay was inversely correlated with birth weight. Clinical parameters varied widely, especially body temperature. Blood glucose changes - particularly hypoglycemia - were common. Leukopenia, usually due to neutropenia, was the most prevalent change in blood cell count. C-reactive protein levels correlated with the immature-to-total neutrophil ratio. Serum TNF-α and IL-10 levels measured early in the course of sepsis were positively correlated with those detected in cord blood. CONCLUSIONS: Clinical and laboratory parameters varied widely among neonates with sepsis in this sample. In neonates who presented with increased cytokine levels at birth, this abnormality persisted throughout the infectious process. |
| | |
Authors:
|
Dulcimar P Campos; Marcos V Silva; Juliana R Machado; Lúcio R Castellano; Virmondes Rodrigues; Cristina H C Barata |
Related Documents
:
|
851207 - A solid-state arteriovenous oxygen difference analyzer for flowing whole blood. 8589537 - The effect of blood flow on oxygen extraction pressures calculated in a model of pointl... 20850787 - Hepatosplanchnic vasoregulation and oxygen consumption during selective aortic blood fl... 7932947 - Prediction of the oxygen cost of the deadlift exercise. 3162577 - Preoperative donation of autologous blood: technique, experience, and community applica... 1420477 - Determination of glutathione isopropyl ester in rat, dog and human blood by high-perfor... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-17 |
Journal Detail:
|
Title: Jornal de pediatria Volume: 86 ISSN: 1678-4782 ISO Abbreviation: J Pediatr (Rio J) Publication Date: 2010 Nov-Dec |
Date Detail:
|
Created Date: 2010-12-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985188R Medline TA: J Pediatr (Rio J) Country: Brazil |
Other Details:
|
Languages: eng Pagination: 509-14 Citation Subset: IM |
Affiliation:
|
Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationship between iron deficiency and anemia in children younger than 4 years.
Next Document: [Titrated oral solution of misoprostol for labour induction: a pilot study].