Document Detail

Early-onset neonatal group B streptococcal infection in London: 1990-1999.
MedLine Citation:
PMID:  15327618     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify the incidence of early-onset group B streptococcal infection and to describe the antecedent maternal risk factors, in order to provide data to inform the design of interventional strategies that could be introduced in the UK to reduce the burden of this infection. DESIGN: A retrospective study with review of case notes of mothers and babies. SETTING: Seven maternity units in London during 1990-1999. Population All cases of proven early-onset neonatal group B streptococcal infection. METHODS: Identification of presence of risk factors that could be used to select women for the offer of intrapartum antibiotic prophylaxis. MAIN OUTCOME MEASURES: Incidence and case-fatality rate of invasive early-onset group B infection. RESULTS: One hundred and forty cases were identified among a birth cohort of 198,388 live births, an incidence of 0.71 per 1000 live births. Twenty-two babies died, a case-fatality rate of 15.6% or 1.1 per 100,000 live births. Women of black ethnic origin, and those who had had a previously affected infant, multiple pregnancy, preterm delivery, prolonged rupture of membranes or intrapartum fever all had a significantly increased risk of delivering an infected infant. CONCLUSIONS: These data suggest that the incidence of early-onset group B streptococcal infection in these London centres is sufficiently high to warrant administration of intrapartum antibiotics to at-risk women.
Albert J Mifsud; Androulla Efstratiou; André Charlett; A Christine McCartney;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  111     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-25     Completed Date:  2004-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1006-11     Citation Subset:  AIM; IM    
Department of Microbiology, Health Protection Agency Collaborating Centre, Royal London Hospital, 37 Ashfield Street, London E1 1BB, UK.
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MeSH Terms
Cross Infection / epidemiology*
Infant, Newborn
London / epidemiology
Maternal Age
Pregnancy Complications, Infectious / epidemiology*
Retrospective Studies
Risk Factors
Streptococcal Infections / epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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