Document Detail


Early-onset myasthenia gravis: clinical characteristics and response to therapy.
MedLine Citation:
PMID:  2079081     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied 59 children with myasthenia gravis (MG). Disease onset was pre-pubertal in 26 patients and post-pubertal in 33. The male to female ratio was 0.62 in the early- and 0.17 in the late-onset groups. The frequency of ocular MG was higher in patients with prepubertal onset. Patients with generalized MG generally showed a good response to thymectomy and corticosteroid therapy proved effective with no major side-effects. In our experience early-onset MG has the same course as in adult life. We recommend thymectomy for generalized disease in childhood, except in very young children on account of possible long-term effects on immunological development. Immunosuppressive therapy should be considered in severely affected patients who do not respond adequately to other therapies.
Authors:
A P Batocchi; A Evoli; M T Palmisani; M Lo Monaco; M Bartoccioni; P Tonali
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  150     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-04-30     Completed Date:  1991-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  66-8     Citation Subset:  IM    
Affiliation:
Institute of Neurology, Catholic University, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Age Factors
Child
Child, Preschool
Cholinesterase Inhibitors / therapeutic use
Eye Diseases / etiology
Female
Follow-Up Studies
Humans
Infant
Male
Myasthenia Gravis / drug therapy,  physiopathology*,  surgery
Plasma Exchange
Prednisone / therapeutic use*
Thymectomy*
Chemical
Reg. No./Substance:
0/Cholinesterase Inhibitors; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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