Document Detail

Early onset conjugated hyperbilirubinemia in newborn infants.
MedLine Citation:
PMID:  16741326     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the causes and related outcomes of early onset conjugated hyperbilirubinemia in a group of newborn infants and to determine the incidence of sepsis in these neonates. METHODS: The charts of 42 babies with conjugated hyperbilirubinemia were retrospectively reviewed. RESULTS: The mean gestational age was 37 weeks and the mean postnatal age at presentation was 10 days. Culture-proven sepsis was identified in 15 babies (35.7% of total). Gram-negative bacteria were isolated in 10 cases and E. coli was the most common of these agents (7 cases). Perinatal hypoxia-ischemia was the second most frequent etiology (7 patients; 16.7% of total). The other diagnoses were blood group incompatibility (n=5), Down syndrome (n=3), cholestasis associated with parenteral nutrition (n=3), neonatal hepatitis (n=2), metabolic liver disease (n=1), biliary atresia (n=1), portal venous thrombosis (n=1) and unknown (n=4). Thirteen babies with sepsis recovered completely with treatment, whereas the prognosis for those with perinatal hypoxia-ischemia was grave (six of seven died). CONCLUSIONS: The findings suggest that early onset cholestatic jaundice in newborn infants is more commonly from non-hepatic causes, so it is reasonable to monitor these infants carefully for a period of time before undertaking time-consuming or invasive investigations towards a primary liver disease.
Filiz Tiker; Aylin Tarcan; Hasan Kilicdag; Berkan Gurakan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  73     ISSN:  0973-7693     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-06-02     Completed Date:  2006-08-03     Revised Date:  2009-07-15    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  409-12     Citation Subset:  IM    
Department of Pediatrics, Baskent University Faculty of Medicine Adana Hospital, Adana, Turkey.
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MeSH Terms
Age of Onset
Hyperbilirubinemia, Neonatal / complications,  epidemiology*,  etiology*
Infant, Newborn
Retrospective Studies
Sepsis / epidemiology,  etiology
Comment In:
Indian J Pediatr. 2007 Jul;74(7):695-6; author reply 696   [PMID:  17699983 ]

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