Document Detail

Early onset cannabis use and progression to other drug use in a sample of Dutch twins.
MedLine Citation:
PMID:  16402286     Owner:  NLM     Status:  MEDLINE    
One possible explanation of the commonly reported associations between early onset cannabis use and elevated risks of other illicit drug use is that early onset cannabis use increases access and availability to other drugs. It was this argument that in part motivated policy changes in the Netherlands that led to the de facto legalization of cannabis there. This study examines, using a co-twin control design, whether previously observed associations between early onset cannabis use and elevated lifetime rates of other illicit drug use would also be observed in a sample of 219 same sex Dutch twin pairs discordant for cannabis use before age 18. After adjustment for covariates, rates of lifetime party drug use (OR=7.4, 95% CI=2.3-23.4), hard drug use (OR=16.5, 95% CI=2.4-111.3), but not regular cannabis use (OR=1.3, 95% CI=0.3-5.1) were significantly elevated in individuals who reported early onset cannabis use, relative to their co-twin who had not used cannabis by age 18. The elevated odds of subsequent illicit drug use in early cannabis users relative to their non early using co-twins suggests that this association could not be explained by common familial risk factors, either genetic or environmental, for which our co-twin methodology provided rigorous control.
Michael T Lynskey; Jacqueline M Vink; Dorret I Boomsma
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study     Date:  2006-01-10
Journal Detail:
Title:  Behavior genetics     Volume:  36     ISSN:  0001-8244     ISO Abbreviation:  Behav. Genet.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-04-28     Completed Date:  2006-10-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0251711     Medline TA:  Behav Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-200     Citation Subset:  IM    
Department of Psychiatry, Washington University in St Louis, MO 63110, USA.
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MeSH Terms
Cross-Sectional Studies
Disease Progression
Diseases in Twins / genetics*
Longitudinal Studies
Marijuana Abuse / diagnosis,  epidemiology,  genetics*
Odds Ratio
Sex Factors
Street Drugs*
Substance-Related Disorders / diagnosis,  epidemiology,  genetics*
Grant Support
Reg. No./Substance:
0/Street Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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