Document Detail

Early onset Morganella morganii sepsis in a newborn infant with emergence of cephalosporin resistance caused by depression of AMPC beta-lactamase production..
MedLine Citation:
PMID:  16567997     Owner:  NLM     Status:  MEDLINE    
A preterm infant with early onset Morganella morganii sepsis was treated with cefotaxime and gentamicin after confirmation of antimicrobial susceptibility. The infant developed persistent ventriculitis caused by the emergence of a cefotaxime-resistant Morganella variant with derepression of its AmpC beta-lactamase. When choosing antibiotic therapy, the risk of development of resistance to cephalosporins should be considered in infections caused by M. morganii and other Gram-negative organisms with inducible AmpC beta-lactamases.
Ajay K Sinha; Stephen T Kempley; Elizabeth Price; Bal K Sharma; David M Livermore
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  25     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-28     Completed Date:  2006-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  376-7     Citation Subset:  IM    
Royal London Hospital, Whitechapel, UK.
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MeSH Terms
Bacteremia / complications,  microbiology
Bacterial Proteins / metabolism*
Cefotaxime / pharmacology
Cephalosporin Resistance*
Enterobacteriaceae Infections / complications,  microbiology*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / microbiology*
Meningitis, Bacterial / complications,  microbiology*
Microbial Sensitivity Tests
Morganella morganii / drug effects*,  enzymology
beta-Lactamases / metabolism*
Reg. No./Substance:
0/Bacterial Proteins; 63527-52-6/Cefotaxime; EC beta-lactamases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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