| Early onset Morganella morganii sepsis in a newborn infant with emergence of cephalosporin resistance caused by depression of AMPC beta-lactamase production.. | |
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MedLine Citation:
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PMID: 16567997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A preterm infant with early onset Morganella morganii sepsis was treated with cefotaxime and gentamicin after confirmation of antimicrobial susceptibility. The infant developed persistent ventriculitis caused by the emergence of a cefotaxime-resistant Morganella variant with derepression of its AmpC beta-lactamase. When choosing antibiotic therapy, the risk of development of resistance to cephalosporins should be considered in infections caused by M. morganii and other Gram-negative organisms with inducible AmpC beta-lactamases. |
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Authors:
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Ajay K Sinha; Stephen T Kempley; Elizabeth Price; Bal K Sharma; David M Livermore |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 25 ISSN: 0891-3668 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-28 Completed Date: 2006-06-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: United States |
Other Details:
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Languages: eng Pagination: 376-7 Citation Subset: IM |
Affiliation:
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Royal London Hospital, Whitechapel, UK. ajay.sinha@bartsandthelondon.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacteremia
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complications,
microbiology Bacterial Proteins / metabolism* Cefotaxime / pharmacology Cephalosporin Resistance* Enterobacteriaceae Infections / complications, microbiology* Female Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / microbiology* Meningitis, Bacterial / complications, microbiology* Microbial Sensitivity Tests Morganella morganii / drug effects*, enzymology beta-Lactamases / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 63527-52-6/Cefotaxime; EC 3.5.2.6/AmpC beta-lactamases; EC 3.5.2.6/beta-Lactamases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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