Document Detail

Early neuroendocrine alterations in female rats following a diet moderately enriched in fat.
MedLine Citation:
PMID:  16133939     Owner:  NLM     Status:  MEDLINE    
1. High-fat diets disrupt metabolic equilibrium and hypothalamic-pituitary-adrenal axis function and may lead to the development of metabolic and endocrine dysfunctions. The early neuroendocrine responses elicited by a combination of short-term metabolic and emotional stressors is not fully elucidated. 2. The purpose of the present study was to determine the impact on female rats, of a short-term enriched in fat diet, combined with an acute stressor. 3. Adult female Wistar rats were fed a fat diet for 7 days and subsequently exposed to 5 min swimming stress. Plasma leptin, insulin, glucose, luteinizing hormone (LH) and corticosterone, along with brain corticosteroid receptors' mRNAs were measured at 1 h post stress. 4. Diet, compared to chow, reduced food intake and body weight gain, increased leptin and LH, and decreased glucose in the periphery. The diet increased plasma corticosterone and reduced GR mRNA in the hippocampus, similarly to swim stress. 5. The diet significantly modified the animals' response to the subsequent swim stress, by blocking further corticosterone rise and GR mRNA reduction. In addition, exposure of diet-fed rats to stress, altered their endocrine response, in terms of leptin and LH. 6. These observations suggest that even short, moderately unbalanced diets can affect peripheral and central components of energy balance, reproduction and stress response.
George Soulis; Efthimia Kitraki; Kyriaki Gerozissis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cellular and molecular neurobiology     Volume:  25     ISSN:  0272-4340     ISO Abbreviation:  Cell. Mol. Neurobiol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-31     Completed Date:  2005-10-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8200709     Medline TA:  Cell Mol Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  869-80     Citation Subset:  IM    
Laboratory of Histology and Embryology, Athens University Medical School, Athens, Greece.
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MeSH Terms
Blood Glucose
Corticosterone / blood
Dietary Fats / pharmacology*
Eating / physiology
Energy Metabolism / physiology*
Homeostasis / physiology
Neurosecretory Systems / metabolism*,  physiopathology
RNA, Messenger / analysis
Rats, Wistar
Receptors, Steroid / genetics
Reproduction / physiology
Stress, Physiological / metabolism*,  physiopathology
Weight Gain / physiology
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Fats; 0/RNA, Messenger; 0/Receptors, Steroid; 50-22-6/Corticosterone

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