| Early myocardial abnormalities in asymptomatic patients with severe isolated congenital aortic regurgitation: an ultrasound tissue characterization and strain rate study. | |
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MedLine Citation:
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PMID: 15682048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Aortic valve regurgitation (AR) in the pediatric population has increased in recent years because of the expanded use of new surgical and hemodynamic procedures. Unlike adult patients, few predictors for the need of operation have been proposed in young asymptomatic or mildly symptomatic patients with AR. METHODS: To unmask early abnormalities of left ventricular (LV) function, 59 participants were enrolled: 14 asymptomatic patients (mean age 18 years) with congenital isolated severe AR and normal LV function (LV ejection fraction > 50%); and 45 healthy control subjects with comparable age and body surface area. All the studied population underwent standard echocardiographic examination, integrated backscatter, and strain rate imaging study. RESULTS: Conventional echocardiographic indices of global LV systolic performance for patients with AR were similar to that of control subjects. Compared with control subjects, integrated backscatter analysis demonstrated a significant reduction in cyclic variation in both septal and posterior walls ( P < .05). LV radial and longitudinal deformation properties for patients with AR were significantly reduced ( P < .05) as assessed by peak systolic strain rate. CONCLUSION: Our results demonstrated the ability of integrated backscatter and strain rate imaging to detect early subclinical abnormalities in young patients with severe congenital AR despite the presence of a normal ejection fraction. |
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Authors:
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Giovanni Di Salvo; Giuseppe Pacileo; Marina Verrengia; Alessandra Rea; Giuseppe Limongelli; Pio Caso; Maria Giovanna Russo; Raffaele Calabrò |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 18 ISSN: 0894-7317 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-31 Completed Date: 2006-09-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 122-7 Citation Subset: IM |
Affiliation:
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Physiopathology of the Cardio-Respiratory System and Associated Biotechnologies, Second University of Naples, Monaldi Hospital, Via Omodeo 45, Naples 80128, Italy. giodisal@yahoo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aortic Valve Insufficiency / congenital*, ultrasonography* Cardiomyopathies / congenital*, ultrasonography* Case-Control Studies Child Female Humans Male Observer Variation Severity of Illness Index Systole Time Factors Ultrasonography, Doppler, Color Ventricular Function, Left |
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