Document Detail

Early mid-trimester serum relaxin, soluble CD163, and cervical length in women at high risk for preterm delivery.
MedLine Citation:
PMID:  16600167     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate the relationship between serum concentrations of relaxin and soluble CD163 with cervical length and preterm delivery in women with previous spontaneous preterm delivery. STUDY DESIGN: Sixty-one of 69 pregnant women with a previous spontaneous preterm had serum relaxin and soluble CD163 measured at week 16 (range, 12-25 weeks). End points were cervical length and gestational age at delivery. RESULTS: Of the 61 women, 26% had >1 previous spontaneous preterm delivery; 84% were black; 87% were unmarried; 13% were smokers, and 39% were delivered before 37 weeks of gestation. Neither relaxin (median, 368 ng/L; range, 83-1493 ng/L) nor soluble CD163 (2.4 mg/L; range, 0.86-6.85 mg/L) correlated with cervical length or gestational age at delivery. Black women had higher relaxin levels (436 vs 205 ng/L; P = .002), but soluble CD163 levels were similar among racial groups. CONCLUSION: Relaxin and soluble CD163 measured at 16 weeks of gestation are not clinically useful predictors of short cervical length or preterm delivery in women with a previous spontaneous preterm delivery.
Ida Vogel; Alice R Goepfert; Holger J Møller; Suzanne Cliver; Poul Thorsen; William W Andrews
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2006-04-05
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  195     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-07-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  208-14     Citation Subset:  AIM; IM    
North Atlantic Neuro-epidemiology Alliances (NANEA), Department of Epidemiology, Institute for Public Health, University of Aarhus, Denmark.
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MeSH Terms
Antigens, CD / blood*
Antigens, Differentiation, Myelomonocytic / blood*
Body Mass Index
Cervix Uteri / pathology*
Predictive Value of Tests
Pregnancy Trimester, Second*
Pregnancy, High-Risk*
Premature Birth / physiopathology*
ROC Curve
Receptors, Cell Surface / blood*
Relaxin / blood*
Grant Support
290-92-0055//PHS HHS
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD163 antigen; 0/Receptors, Cell Surface; 9002-69-1/Relaxin

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