Document Detail

Early metabolic alterations during the development of experimentally induced cardiac hypertrophy.
MedLine Citation:
PMID:  6452127     Owner:  NLM     Status:  MEDLINE    
The main biochemical features of protein synthesis in the myocardium are described as well as several metabolic alterations that occur during the very early stages in three models of cardiac hypertrophy resulting from pressure overload in vivo and in vitro, application of a high dose of isoprenaline and repeated daily administration of triiodothyronine. Furthermore, both mechanical and metabolic factors possibly participating in the development of cardiac hypertrophy are discussed and critically evaluated.
H G Zimmer; E Gerlach
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  30     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1980  
Date Detail:
Created Date:  1981-05-13     Completed Date:  1981-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  2001-7     Citation Subset:  IM    
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MeSH Terms
Adenosine Triphosphate / metabolism
Amino Acids / metabolism
Blood Pressure / drug effects
Cardiomegaly / chemically induced,  metabolism*
Energy Metabolism* / drug effects
Isoproterenol / pharmacology
Muscle Proteins / biosynthesis
Myocardium / metabolism
Triiodothyronine / pharmacology
Reg. No./Substance:
0/Amino Acids; 0/Muscle Proteins; 56-65-5/Adenosine Triphosphate; 6893-02-3/Triiodothyronine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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