| Early maternal undernutrition programs increased feed intake, altered glucose metabolism and insulin secretion, and liver function, in aged female offspring. | |
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MedLine Citation:
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PMID: 22277936 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Insulin resistance and obesity are components of the metabolic syndrome which includes development of cardiovascular disease and diabetes with advancing age. The thrifty phenotype hypothesis suggests that offspring of poorly nourished mothers are predisposed to the various components of the metabolic syndrome due to adaptations made during fetal development. We assessed the effects of maternal nutrient restriction in early gestation on feeding behavior, insulin/glucose dynamics, body composition and liver function in aged female offspring of ewes fed either a nutrient restricted (NR: 50% National Research Council (NRC) recommendations) or control (C: 100% NRC) diet from 28 to 78 days of gestation, after which both groups were fed at 100% of NRC from day 79 to lambing and through lactation. Female lambs born to NR and C dams were reared as a single group from weaning, and thereafter fed 100% NRC recommendations until assigned to this study at 6 years of age. These female offspring were evaluated by a frequently sampled intravenous glucose tolerance test, followed by dual energy x-ray absorptiometry for body composition analysis prior to and after ad libitum feeding of a highly palatable pelleted diet for 11 wks with automated monitoring of feed intake (GrowSafe Systems Ltd.). Aged female offspring born to NR ewes demonstrated greater and more rapid feed intake, greater body weight gain and efficiency of gain, lower insulin sensitivity, higher insulin secretion, and greater hepatic lipid and glycogen content than offspring from C ewes. These data confirm an increased metabolic "thriftiness" of offspring born to NR mothers which continues into advanced age, possible predisposing these offspring to metabolic disease. |
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Authors:
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Lindsey Ann George; Liren Zhang; Nuermaimaiti Tuersunjiang; Yan Ma; Nathan M Long; Adam B Uthlaut; Derek T Smith; Peter W Nathanielsz; Stephen P Ford |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: - ISSN: 1522-1490 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Wyoming. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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