Document Detail

Early maternal stress and health behaviours and offspring expression of psychosis in adolescence.
MedLine Citation:
PMID:  15458559     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: It has been suggested that influences operating early in life may affect the risk of postpubertal psychosis outcomes. This hypothesis was tested using a broad outcome of psychotic symptoms expressed in adolescence (prevalence: 15.6%). METHOD: Findings are based on a longitudinal, population-based cohort study of 963 adolescents aged 15-20 years and their parents in the area of Munich, Germany. Trained psychologists assessed adolescents with the Munich-Composite International Diagnostic Interview. Independently, direct diagnostic interviews were conducted with the parents. RESULTS: A range of medical complications of pregnancy and delivery, including lower birth weight, were not associated with the psychosis outcome. However, a number of maternal health behaviours and experiences did show associations, independent of confounders. CONCLUSION: Not maternally reported medical complications of pregnancy and delivery, but maternal prenatal health behaviours predicted expression of psychosis along a continuum in adolescence. This effect may either be direct or constitute a proxy for later postnatal maternal behaviours associated with psychosis risk in the offspring.
J Spauwen; L Krabbendam; R Lieb; H U Wittchen; J van Os
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  110     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-01     Completed Date:  2005-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  356-64     Citation Subset:  IM    
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, 6200 MD Maastricht, The Netherlands.
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MeSH Terms
Adolescent Behavior
Longitudinal Studies
Middle Aged
Mother-Child Relations
Psychotic Disorders / etiology*,  psychology*
Stress, Psychological*

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