Document Detail


Early marker for Alzheimer's disease: hippocampus T1rho (T(1rho)) estimation.
MedLine Citation:
PMID:  19388096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the T1rho (T(1rho)) MRI relaxation time in hippocampus in the brain of Alzheimer's disease (AD), mild cognitive impairment (MCI), and control, and to determine whether the T(1rho) shows any significant difference between these cohorts.
MATERIALS AND METHODS: With informed consent, AD (n = 49), MCI (n = 48), and age-matched control (n = 31) underwent T(1rho) MRI on a Siemens 1.5T Scanner. T(1rho) values were automatically calculated from the left and right hippocampus region using in-house developed software. Bonferroni post-hoc multiple comparisons was performed to compare the T(1rho) value among the different cohorts.
RESULTS: Significantly higher T(1rho) values were observed both in AD (P = 0.000) and MCI (P = 0.037) cohorts compared to control; also, the T(1rho) in AD was significantly high over (P = 0.032) MCI. Hippocampus T(1rho) was 13% greater in the AD patients than control, while in MCI it was 7% greater than control. Hippocampus T(1rho) in AD patients was 6% greater than MCI.
CONCLUSION: Higher hippocampus T(1rho) values in the AD patients might be associated with the increased plaques burden. A follow-up study would help to determine the efficacy of T(1rho) values as a predictor of developing AD in the control and MCI individuals.
Authors:
Mohammad Haris; Erin McArdle; Matthew Fenty; Anup Singh; Christos Davatzikos; John Q Trojanowski; Elias R Melhem; Christopher M Clark; Arijitt Borthakur
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  29     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-28     Completed Date:  2009-05-28     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1008-12     Citation Subset:  IM    
Affiliation:
MMRRCC, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6100, USA. haris@mail.mmrrcc.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / diagnosis*
Biological Markers
Cognition Disorders / diagnosis*
Female
Hippocampus / pathology*
Humans
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Male
Plaque, Amyloid / pathology*
Prognosis
Reproducibility of Results
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
P41 RR002305/RR/NCRR NIH HHS; P41 RR002305-236875/RR/NCRR NIH HHS; P41 RR002305-246021/RR/NCRR NIH HHS; P41 RR002305-255549/RR/NCRR NIH HHS; R01 AG014971-08S1/AG/NIA NIH HHS; R01 AG014971-09/AG/NIA NIH HHS; RR02305/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections

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