| Early manifestations of disseminated Mycobacterium avium complex disease: a prospective evaluation. | |
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MedLine Citation:
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PMID: 9207358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A nested case-control study was conducted in two trials of prophylaxis for Mycobacterium avium complex (MAC) infection to describe the specific signs, symptoms, and laboratory abnormalities of MAC disease in AIDS. Patients had < or =200/mm3 CD4 cells and a prior AIDS-defining illness. Of 571 patients, 102 (17.9%) developed MAC bacteremia during a mean follow-up of 256 days. Among cases of MAC disease, 90 were compared with 180 matched controls. Patients with MAC disease were more likely than controls to have lower weights (66.3 vs. 71.1 kg, P = .001) and Karnofsky scores (74.3 vs. 84.4, P < .001); a higher proportion had fever (48% vs. 26%, P = .003), abdominal pain (23% vs. 13%, P =.05), decreased hemoglobin levels (10.9 vs. 12.1 g/dL, P < .001), and elevated alkaline phosphatase (203 vs. 138 U/L, P=.04) and lactate dehydrogenase (334 vs. 280 U/L, P = .02) levels. Characteristics of MAC disease that occurred before bacteremia were weight loss (3 months prior), fever (2 months), and anemia and elevated lactate dehydrogenase (1 month). These data suggest that patients have symptomatic MAC disease for several months prior to the occurrence of bacteremia. |
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Authors:
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F M Gordin; D L Cohn; P M Sullam; J R Schoenfelder; B A Wynne; C R Horsburgh |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 176 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-07-17 Completed Date: 1997-07-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 126-32 Citation Subset: AIM; IM; X |
Affiliation:
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Division of Infectious Diseases, Department of Veterans Affairs Medical Center, and Georgetown University, Washington, DC 20422, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bacteremia / etiology Double-Blind Method Female Humans Male Middle Aged Mycobacterium avium-intracellulare Infection / complications*, mortality Prospective Studies Survival Rate Weight Loss |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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