Document Detail

Early low volume oral synbiotic/prebiotic supplemented enteral stimulation of the gut in patients with severe acute pancreatitis: a prospective feasibility study.
MedLine Citation:
PMID:  22571076     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Experience with administration of synbiotics (prebiotics/probiotics) in patients with severe acute pancreatitis (SAP) has demonstrated immunomodulatory capacity. The aim of this trial was evaluation of the feasibility and perspective of early clinical application of oral synbiotic/prebiotic supplements in patients with SAP.
METHODS: 90 SAP patients were enrolled during the period from 2005-2008. Patients were stratified according to the feeding mode. CONTROL (n = 32) group received standard whole protein feeding formula. SYNBIO (n = 30) and FIBRE groups (n = 28) received early (within first 24-48 hours) synbiotic or prebiotic supplements. Oral administration of synbiotics or prebiotics was commenced when patients were able to sip water.
RESULTS: Daily provided average volume and calories of synbiotic/prebiotic blends were smaller compared to the CONTROL, p = 0.001. Oral administration of synbiotic/prebiotic supplements was associated with lower infection rate (pancreatic and peripancreatic necrosis) compared to the CONTROL, (p = 0.03; p = 0.001), lower rate of surgical interventions, p = 0.005, shorter ICU (p = 0.05) and hospital stay (p = 0.03). Synbiotic supplemented enteral stimulation of the gut resulted in reduced mortality rate compared to the CONTROL, p = 0.02.
CONCLUSION: Early low volume oral synbiotic/prebiotic supplemented enteral stimulation of the gut seems to be a potentially valuable complement to the routine treatment protocol of SAP.
H Plaudis; G Pupelis; K Zeiza; V Boka
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta chirurgica Belgica     Volume:  112     ISSN:  0001-5458     ISO Abbreviation:  Acta Chir. Belg.     Publication Date:    2012 Mar-Apr
Date Detail:
Created Date:  2012-05-10     Completed Date:  2012-06-14     Revised Date:  2012-11-27    
Medline Journal Info:
Nlm Unique ID:  0370571     Medline TA:  Acta Chir Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  131-8     Citation Subset:  IM    
Department of Surgery, Riga Eastern Clinical University Hospital "Gailezers", Riga, Latvia.
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MeSH Terms
Acute Disease
Case-Control Studies
Dietary Fiber / administration & dosage,  therapeutic use*
Feasibility Studies
Pancreatitis / drug therapy*,  mortality,  pathology*
Probiotics / administration & dosage,  therapeutic use*
Prospective Studies
Risk Factors
Severity of Illness Index
Survival Analysis
Synbiotics* / utilization
Treatment Outcome
Comment In:
Acta Chir Belg. 2012 Sep-Oct;112(5):403   [PMID:  23175934 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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