Document Detail

Early lipid supply and neurological development at one year in very low birth weight (VLBW) preterm infants.
MedLine Citation:
PMID:  22264437     Owner:  NLM     Status:  Publisher    
BACKGROUND: The rapid growth of the developing brain during early post-natal life makes it particularly vulnerable to a nutritional deficit. The neurological development of the very low birth weight preterm infant could be related to early lipid supply. AIMS: To evaluate in preterm infants of gestational age ≤28weeks of amenorrhea (WA) the relations between the neurological development determined at a corrected age of one year using the test of Brunet-Lézine and 1) the cumulative intakes of proteins, carbohydrates, lipids and energy during the first 28days of life and 2) the weight gain in the first 28days of life. MATERIALS AND METHODS: Study of a mono-centric cohort of 48 premature infants of gestational age ≤28 WA consecutively hospitalized and followed longitudinally up to a corrected age of one year. RESULTS: In simple univariate analysis, there was a significant correlation between the developmental quotient (DQ) at a corrected age of one year and the cumulative intake of energy and lipids at 14days of life (p=0.02, p=0.01, respectively), the number of days to reach the minimum weight (p=0.02) and the weight gain from birth to D28 of life (p=0.04). There was no correlation between the DQ and early intake of proteins or carbohydrates. In multivariate analysis, only the association between the DQ at one year of corrected age and the cumulative lipid intake at 14days of life remained statistically significant (p=0.04). CONCLUSION: Our study demonstrates the importance of early lipid supply during the first two weeks of life for the neurological development at a corrected age of one year of very low birth weight preterm infants.
Sergio Eleni Dit Trolli; Elsa Kermorvant-Duchemin; Catherine Huon; Dominique Bremond-Gignac; Alexandre Lapillonne
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-18
Journal Detail:
Title:  Early human development     Volume:  -     ISSN:  1872-6232     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
APHP, Saint-Vincent de Paul-Cochin hospital, Paris, France.
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