Document Detail

Early life response to infection.
MedLine Citation:
PMID:  23449137     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Sepsis is a serious complication in preterm and term infants, yet our understanding of how neonates respond to infection remains poorly defined.
RECENT FINDINGS: We describe our current clinical, cellular and molecular understanding of the neonatal host systemic response to infection. We find that host resilience essentially relies on innate immune mechanisms despite there being a complete repertoire of cellular components of the adaptive immune arm. The functional interplay between metabolism, immunity and microbiome further suggests that neonatal vulnerability to infection is not simply due to immaturity of the immune system but how immune homeostasis is regulated. Further research is required for exploring regulatory homeostatic mechanisms between innate and adaptive responses and microbiome colonization at birth, but which can impart an adverse trajectory to infection.
SUMMARY: The vulnerability and resilience against infection in neonates, including extreme preterm infants, still remains poorly understood. We advance the view that greater consideration should be given to understanding the set point in the regulation of homeostatic control of innate and adaptive immunity and its interplay with metabolism and the newly acquired microbiome.
Peter Ghazal; Paul Dickinson; Claire L Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in infectious diseases     Volume:  26     ISSN:  1473-6527     ISO Abbreviation:  Curr. Opin. Infect. Dis.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-23     Completed Date:  2013-09-26     Revised Date:  2014-07-16    
Medline Journal Info:
Nlm Unique ID:  8809878     Medline TA:  Curr Opin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-8     Citation Subset:  IM    
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MeSH Terms
Adaptive Immunity / physiology*
Host-Pathogen Interactions / immunology
Immunity, Cellular / physiology
Immunity, Innate / physiology*
Infant, Newborn
Infant, Premature / immunology
Metagenome / immunology
Sepsis / immunology*
T-Lymphocytes / immunology
Grant Support
ETM/202//Chief Scientist Office; G0701289//Medical Research Council; //Biotechnology and Biological Sciences Research Council; //Medical Research Council; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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