| Early life factors in the pathogenesis of osteoporosis. | |
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MedLine Citation:
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PMID: 19968918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Osteoporosis is a major public health burden through associated fragility fractures. Bone mass, a composite of bone size and volumetric density, increases through early life and childhood to a peak in early adulthood. The peak bone mass attained is a strong predictor of future risk of osteoporosis. Evidence is accruing that environmental factors in utero and in early infancy may permanently modify the postnatal pattern of skeletal growth to peak and thus influence risk of osteoporosis in later life. This article describes the latest data in this exciting area of research, including novel epigenetic and translation work, which should help to elucidate the underlying mechanisms and give rise to potential public health interventions to reduce the burden of osteoporotic fracture in future generations. |
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Authors:
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Chivon Winsloe; Susie Earl; Elaine M Dennison; Cyrus Cooper; Nicholas C Harvey |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current osteoporosis reports Volume: 7 ISSN: 1544-2241 ISO Abbreviation: Curr Osteoporos Rep Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-08 Completed Date: 2010-02-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101176492 Medline TA: Curr Osteoporos Rep Country: United States |
Other Details:
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Languages: eng Pagination: 140-4 Citation Subset: IM |
Affiliation:
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Medical Research Council Epidemiology Resource Centre, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Animals Bone Density Calcium / metabolism Diet Female Humans Infant, Newborn Male Osteoporosis / etiology*, physiopathology Osteoporosis, Postmenopausal / etiology Placenta / metabolism Pregnancy Prenatal Exposure Delayed Effects* Vitamin D / blood |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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