Document Detail


Early life experience alters behavioral responses to sweet food and accumbal dopamine metabolism.
MedLine Citation:
PMID:  19744551     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal handling in rats persistently alters behavioral parameters and responses to stress. Such animals eat more sweet food in adult life, without alterations in lab chow ingestion. Here, we show that neonatally handled rats display greater incentive salience to a sweet reward in a runway test; however they are less prone to conditioned place preference and show less positive hedonic reactions to sweet food. When injected with methylphenidate (a dopamine mimetic agent), non-handled rats increase their sweet food ingestion in the fasted state, while neonatally handled rats do not respond. We did not observe any differences regarding baseline general ambulatory activity between the groups. A lower dopamine metabolism in the nucleus accumbens was observed in handled animals, without differences in norepinephrine content. We suggest that early handling leads to a particular response to positive reinforcers such as palatable food, in a very peculiar fashion of higher ingestion but lower hedonic impact, as well as higher incentive salience, but diminished dopaminergic metabolism in the nucleus accumbens.
Authors:
P P Silveira; A K Portella; S A C N Assis; F B Nieto; L A Diehl; L M Crema; W Peres; G Costa; C Scorza; J A Quillfeldt; A B Lucion; C Dalmaz
Publication Detail:
Type:  Journal Article     Date:  2009-09-08
Journal Detail:
Title:  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience     Volume:  28     ISSN:  1873-474X     ISO Abbreviation:  Int. J. Dev. Neurosci.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-27     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8401784     Medline TA:  Int J Dev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  111-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 ISDN. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Animals, Newborn
Conditioning, Classical / physiology
Diet
Dopamine / metabolism*
Dopamine Uptake Inhibitors / pharmacology
Fasting
Feeding Behavior / drug effects,  physiology*
Male
Methylphenidate / pharmacology
Motor Activity / drug effects,  physiology
Norepinephrine / metabolism
Nucleus Accumbens / physiopathology*
Rats
Rats, Wistar
Reward
Space Perception / physiology
Stress, Psychological / physiopathology*
Chemical
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 207ZZ9QZ49/Methylphenidate; VTD58H1Z2X/Dopamine; X4W3ENH1CV/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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