| Early life experience alters behavioral responses to sweet food and accumbal dopamine metabolism. | |
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MedLine Citation:
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PMID: 19744551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal handling in rats persistently alters behavioral parameters and responses to stress. Such animals eat more sweet food in adult life, without alterations in lab chow ingestion. Here, we show that neonatally handled rats display greater incentive salience to a sweet reward in a runway test; however they are less prone to conditioned place preference and show less positive hedonic reactions to sweet food. When injected with methylphenidate (a dopamine mimetic agent), non-handled rats increase their sweet food ingestion in the fasted state, while neonatally handled rats do not respond. We did not observe any differences regarding baseline general ambulatory activity between the groups. A lower dopamine metabolism in the nucleus accumbens was observed in handled animals, without differences in norepinephrine content. We suggest that early handling leads to a particular response to positive reinforcers such as palatable food, in a very peculiar fashion of higher ingestion but lower hedonic impact, as well as higher incentive salience, but diminished dopaminergic metabolism in the nucleus accumbens. |
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Authors:
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P P Silveira; A K Portella; S A C N Assis; F B Nieto; L A Diehl; L M Crema; W Peres; G Costa; C Scorza; J A Quillfeldt; A B Lucion; C Dalmaz |
Publication Detail:
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Type: Journal Article Date: 2009-09-08 |
Journal Detail:
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Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience Volume: 28 ISSN: 1873-474X ISO Abbreviation: Int. J. Dev. Neurosci. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8401784 Medline TA: Int J Dev Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 111-8 Citation Subset: IM |
Copyright Information:
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Copyright 2009 ISDN. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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PPG Neuroci?ncias, Instituto de Ci?ncias B?sicas da Sa?de, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil. raty@cpovo.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Animals, Newborn Conditioning, Classical / physiology Diet Dopamine / metabolism* Dopamine Uptake Inhibitors / pharmacology Fasting Feeding Behavior / drug effects, physiology* Male Methylphenidate / pharmacology Motor Activity / drug effects, physiology Norepinephrine / metabolism Nucleus Accumbens / physiopathology* Rats Rats, Wistar Reward Space Perception / physiology Stress, Psychological / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Uptake Inhibitors; 113-45-1/Methylphenidate; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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