Document Detail

Early-life domestic aeroallergen exposure and IgE sensitization at age 4 years.
MedLine Citation:
PMID:  16950296     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although it is widely assumed that childhood sensitization to common aeroallergens is directly related to allergen exposure in early life, few longitudinal studies have investigated this issue, and available data are scarce and mainly limited to high-risk groups. OBJECTIVE: We sought to assess the role of early exposure to 2 major household aeroallergens (Der p 1 and Fel d 1) in sensitization at the age of 4 years. METHODS: Pregnant women and their children were recruited for the Asthma Multicenter Infant Cohort Study. Three cohorts (Ashford in the United Kingdom and Menorca and Barcelona in Spain) followed the same research protocol. A total of 1611 newborn children were initially included in the cohort, from whose homes we collected dust samples at 3 months of age for 1474; Der p 1 and Fel d 1 levels were measured. Of these children, we obtained blood for specific IgE determination in 1019. RESULTS: The risk of Fel d 1 sensitization increased with exposure in a nonlinear manner. No association was found between specific IgE to Der p 1 and aeroallergen levels of exposure at early life in 2 centers, but a positive association was observed in the third. CONCLUSIONS: The dose-response relationships between allergen exposure and sensitization differ between allergens and might vary between different locales. The hypothesis that sensitization to house dust mite is directly related to levels of allergen exposure might not apply to the general population or to different ranges of exposure. CLINICAL IMPLICATIONS: Aeroallergen avoidance might not have any important effect on the incidence of sensitization.
Matias Torrent; Jordi Sunyer; Laura Muñoz; Paul Cullinan; Maria Victoria Iturriaga; Cecilia Figueroa; Oriol Vall; Anthony Newman Taylor; Josep Maria Anto
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2006-07-03
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  118     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2006-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  742-8     Citation Subset:  AIM; IM    
Menorca Health Area, ib-salut, Menorca, Spain.
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MeSH Terms
Air Pollution, Indoor*
Allergens / immunology*
Antigens, Dermatophagoides / immunology
Child, Preschool
Cohort Studies
Dust / immunology
Glycoproteins / immunology
Immunoglobulin E / biosynthesis*,  blood*
Infant, Newborn
Inhalation Exposure*
Prospective Studies
Pyroglyphidae / immunology
Reg. No./Substance:
0/Allergens; 0/Antigens, Dermatophagoides; 0/Dust; 0/Fel d 1 protein, Felis domesticus; 0/Glycoproteins; 37341-29-0/Immunoglobulin E; EC 3.4.22.-/Dermatophagoides pteronyssinus antigen p 1

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