Document Detail

Early-life determinants of overweight and obesity: a review of systematic reviews.
MedLine Citation:
PMID:  20331509     Owner:  NLM     Status:  MEDLINE    
The aim of this paper was to review the evidence for early-life (from conception to 5 years of age) determinants of obesity. The design is review of published systematic reviews. Data sources included Medline, Embase, Web of Science, Cochrane Library, CINAHL, PsycINFO. Identification of 22 eligible reviews from a database of 12,021 independent publications. Quality of selected reviews assessed using the Assessment of Multiple Systematic Reviews score. Articles published after the reviews were used to confirm results. No review was classified as high quality, 11 as moderate and 11 as low. Factors associated with later overweight and obesity: maternal diabetes, maternal smoking, rapid infant growth, no or short breastfeeding, obesity in infancy, short sleep duration, <30 min of daily physical activity, consumption of sugar-sweetened beverages. Other factors were identified as potentially relevant, although the size of their effect is difficult to estimate. Maternal smoking, breastfeeding, infant size and growth, short sleep duration and television viewing are supported by better-quality reviews. It is difficult to establish a causal association between possible determinants and obesity, and the relative importance of each determinant. Future research should focus on early-life interventions to confirm the role of protective and risk factors and to tackle the high burden obesity represents for present and future generations.
L Monasta; G D Batty; A Cattaneo; V Lutje; L Ronfani; F J Van Lenthe; J Brug
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Obesity reviews : an official journal of the International Association for the Study of Obesity     Volume:  11     ISSN:  1467-789X     ISO Abbreviation:  Obes Rev     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-23     Completed Date:  2010-11-22     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  100897395     Medline TA:  Obes Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  695-708     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. obesity reviews © 2010 International Association for the Study of Obesity.
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MeSH Terms
Breast Feeding / epidemiology*
Child Nutritional Physiological Phenomena / physiology*
Child, Preschool
Dietary Sucrose / administration & dosage
Infant Nutritional Physiological Phenomena / physiology
Infant, Newborn
Maternal Nutritional Physiological Phenomena / physiology*
Obesity / etiology*,  prevention & control
Prenatal Exposure Delayed Effects*
Risk Factors
Sleep Deprivation / physiopathology
Smoking / adverse effects
Time Factors
Grant Support
MC_U130059821//Medical Research Council
Reg. No./Substance:
0/Dietary Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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