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Early and late urodynamic assessment of simplified Indiana pouch with multiple taeniamyotomies.
MedLine Citation:
PMID:  20518766     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: To compare the early and late urodynamic assessment of simplified Indiana pouch with multiple taeniamyotomies (SIPMT).
PATIENTS AND METHODS: Between April 1999 and May 2005, 62 consecutive patients underwent radical cystectomy (RC) and SIMPT. Cystometry and efferent tract pressure profilometry were performed at 12 (early) and 48 (late) months after RC in 32 patients. The efferent tract of the reservoir was the appendix in 62.5% of patients and an ileum invagination nipple in 37.5%. All patients were asked to complete questionnaires on HRQL: the European Organization for Cancer Research and Treatment of Cancer Quality of life Questionnaire version 3.0 (EORTC QLQ-C30) and the bladder cancer-specific module (EORTC QLQ-BLM30).
RESULTS: There was no significant change in cystometric capacity (median 627.5 vs 607.5 mL, P = 0.79), while end-filling pressure (median 28 vs 18 cmH₂O) and amplitude of involuntary contractions (median 38 vs 32 cmH₂O; both P < 0.001) decreased. Efferent tract-closing pressure increased in the appendicostomies (median 74.5 vs 91.0 cmH₂O, P= 0.029) and decreased in the ileostomies (median 72.5 vs 63 cmH₂O, P = 0.015), also the leakage rates during the pressure peaks decreased from 15% to 5% in appendicostomies, while there was no change in those with ileostomies (15%). At late evaluation, daytime and night-time continence rates were 94% and 88%, respectively, in patients with appendicostomies, and 90% and 85%, respectively, in those with ileostomies. A good HRQL was determined by the EORTC QLQ-C30 and QLQ-BLM30 questionnaires.
CONCLUSIONS: At 48 months after surgery SIPMT maintained an adequate capacity with low internal pressure, good continence rates and HRQL. When feasible, appendicostomy should be performed, as it was associated with better continence.
Authors:
Mariaconsiglia Ferriero; Giuseppe Simone; Rocco Papalia; Salvatore Guaglianone; Ester Forastiere; Michele Gallucci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BJU international     Volume:  107     ISSN:  1464-410X     ISO Abbreviation:  BJU Int.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  112-6     Citation Subset:  IM    
Copyright Information:
© 2010 THE AUTHORS. JOURNAL COMPILATION © 2010 BJU INTERNATIONAL.
Affiliation:
Departments of Urology, Regina Elena National Cancer Institute, Rome, Italy. m.ferriero@unicampus.it
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