Document Detail


Early kinetics of thyroid trap in normal human patients and in thyroid diseases.
MedLine Citation:
PMID:  6166476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A six-compartment model is proposed for the study of early iodine kinetics (150 min) in the human thyroid gland including three compartments for extrathyroidal spaces. The results were compared with those obtained with an open two-compartment thyroid model. In six euthyroid subjects the values of the unidirectional thyroid clearance R41 = 86 +- 25 ml/min and of the irreversible clearance R65 = 22 +- 9 ml/min were consistent with those generally accepted. With TSH stimulation a clear increase in the thyroidal pump effectiveness was found without an increase in the irreversible clearance. In four untreated thyrotoxic patients a tenfold increase in the unidirectional thyroid clearance was found (p less than 0.01). The binding rate was much less increased and overlapped with the normal values; a large increase in the iodide compartment volumes was found. The unidirectional clearance remained elevated in seven patients after Carbimazole treatment and the binding rates were reduced. The six-compartment model demonstrated a rapid exit from the bound iodine compartment. In three of four goitrous patients studied, the thyroid unidirectional clearance was significantly increased ( p less than 0.001). The volumes of the iodide compartments were much higher than those observed in the other groups. The method was applied to analyse the kinetics of the different parts of the thyroid.
Authors:
J P Bazin; P Fragu; R Di Paola; M Di Paola; M Tubiana
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  6     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1981  
Date Detail:
Created Date:  1981-09-25     Completed Date:  1981-09-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  317-26     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antithyroid Agents / therapeutic use
Carbimazole / therapeutic use
Goiter / metabolism
Humans
Hyperthyroidism / drug therapy,  metabolism
Iodine / metabolism*
Kinetics
Models, Biological
Thyroid Diseases / metabolism*
Chemical
Reg. No./Substance:
0/Antithyroid Agents; 22232-54-8/Carbimazole; 7553-56-2/Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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