| Early ischemic lesions following subarachnoid hemorrhage: common cold remedy as precipitating factor? | |
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MedLine Citation:
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PMID: 21510236 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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A 46-year-old woman presented with tetraplegia contrasting with a relatively preserved consciousness following aneurysmal subarachnoid hemorrhage (SAH). Multiple ischemic lesions were detected by magnetic resonance imaging (MRI), in the absence of vasospasm or signs of increased intracranial pressure. During the weeks before SAH, the patient had repeatedly used a nasal decongestant containing phenylephrine. After coiling of the aneurysm harboured by the right posterior cerebral artery, symptomatic vasospasm developed in the territory of the right middle cerebral artery and required aggressive therapy by intra-arterial infusion of milrinone followed by continuous intravenous administration. Follow-up MRI did not reveal new ischemic lesions. Echocardiography had demonstrated the presence of a patent foramen ovale. At 3 months follow-up, a major motor deficit persisted with akinetic mutism. The mechanisms of multiple early infarction following aneurysmal SAH are still debated, as vasospasm is usually not seen on the first imaging. Among precipitating factors of microvascular vasospasm, vasoactive substances like phenylephrine, may play a significant role. |
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Authors:
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Sandrine Genonceaux; Guy Cosnard; Françoise Van De Wyngaert; Philippe Hantson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurologica Belgica Volume: 111 ISSN: 0300-9009 ISO Abbreviation: Acta Neurol Belg Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0247035 Medline TA: Acta Neurol Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 59-61 Citation Subset: IM |
Affiliation:
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Department of Intensive Care, Université catholique de Louvain, Brussels, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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