| Early intracardiac thrombosis in preterm infants and thrombolysis with recombinant tissue type plasminogen activator. | |
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MedLine Citation:
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PMID: 11420328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the incidence of catheter related thrombosis and to test the efficacy of recombinant tissue type plasminogen activator (rt-PA) in preterm infants. STUDY DESIGN: From January 1995 to December 1998, echocardiography was performed in the first few days of life in 76 very low birthweight (< or = 1500 g) infants out of a total of 147 having an umbilical catheter placed. When intracardiac thrombosis was diagnosed, rt-PA infusion was performed. RESULTS: Four infants (5%) developed an intracardiac thrombosis during the first few days of life. In three of them, rt-PA at a dose of 0.4-0.5 mg/kg in a 20-30 minute bolus led to dissolution of the clot. One patient received a three hour infusion after the bolus, at a dose of 0.1 mg/kg/h, with resolution of the thrombus. No systemic effects were observed after rt-PA infusion. CONCLUSIONS: Early thrombosis may occur as a complication of umbilical catheterisation in preterm infants; early echocardiographic detection of this disorder allows complete, safe, and rapid lysis with rt-PA. |
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Authors:
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F Ferrari; F Vagnarelli; G Gargano; M F Roversi; O Biagioni; A Ranzi; G B Cavazzuti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 85 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-06-22 Completed Date: 2001-08-02 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: England |
Other Details:
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Languages: eng Pagination: F66-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Paediatrics, Division of Neonatology, Modena University Hospital, Via del Pozzo, 41100 Modena, Italy. Ferrarif@unimo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Catheterization, Peripheral
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adverse effects Coronary Thrombosis / diagnosis, drug therapy*, etiology Echocardiography, Doppler Female Fibrinolytic Agents / therapeutic use* Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / diagnosis, drug therapy*, etiology Male Thrombolytic Therapy / methods* Tissue Plasminogen Activator / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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