Document Detail


Early intervention with suplatast tosilate for prophylaxis of pediatric atopic asthma: a pilot study.
MedLine Citation:
PMID:  19210644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The onset of asthma may be related to Th2 cytokine dominance at the time when food allergies occur several months after birth. This study investigated the effectiveness of early intervention with a Th2 cytokine inhibitor (suplatast tosilate) for prevention of asthma in infants with food allergies and atopic dermatitis. Suplatast tosilate dry syrup (6 mg/kg daily) or a histamine H(1)-blocker (ketotifen fumarate dry syrup: 0.06 mg/kg daily) was administered randomly to 53 infants with atopic dermatitis caused by food allergies. The primary endpoints were the incidence of asthma and the time to the onset of wheezing. The peripheral blood Th1/Th2 ratio, total IgE level, and eosinophil count were measured before and after treatment. After 24 months of treatment, the prevalence of asthma was significantly lower in the suplatast group (20.8%) than in the ketotifen group (65.6%, p < 0.01). Additionally, the time from the start of treatment to the initial episode of wheezing for infants who developed asthma was significantly longer in the suplatast group than the ketotifen group (p < 0.01). Furthermore, the eosinophil count was significantly decreased by suplatast treatment (p < 0.05), and there was a significant difference between the suplatast and ketotifen groups with respect to both the eosinophil count (p < 0.01) and the Th1/Th2 ratio (p < 0.05). The results of the present pilot study suggest that suplatast tosilate is useful for the primary prevention of wheezing and asthma in children.
Authors:
Shigemi Yoshihara; Mika Ono; Yumi Yamada; Hironobu Fukuda; Toshio Abe; Osamu Arisaka
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-02-02
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  20     ISSN:  1399-3038     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-13     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  486-92     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan. shigemi@dokkyomed.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Allergens / adverse effects,  immunology
Animals
Anti-Allergic Agents* / administration & dosage,  therapeutic use
Arylsulfonates* / administration & dosage,  therapeutic use
Asthma / epidemiology,  prevention & control*
Chemoprevention
Dermatitis, Atopic* / drug therapy,  etiology
Egg White / adverse effects
Female
Food Hypersensitivity* / complications,  drug therapy,  etiology
Humans
Hypersensitivity, Immediate / prevention & control*
Incidence
Infant
Ketotifen / pharmacology,  therapeutic use
Male
Milk / adverse effects,  immunology
Pilot Projects
Respiratory Sounds / drug effects*
Sulfonium Compounds* / administration & dosage,  therapeutic use
Th1 Cells / immunology
Th2 Cells / immunology
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Allergens; 0/Anti-Allergic Agents; 0/Arylsulfonates; 0/Sulfonium Compounds; 34580-13-7/Ketotifen; 94055-76-2/suplatast tosilate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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