| Early intervention with suplatast tosilate for prophylaxis of pediatric atopic asthma: a pilot study. | |
| | |
MedLine Citation:
|
PMID: 19210644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The onset of asthma may be related to Th2 cytokine dominance at the time when food allergies occur several months after birth. This study investigated the effectiveness of early intervention with a Th2 cytokine inhibitor (suplatast tosilate) for prevention of asthma in infants with food allergies and atopic dermatitis. Suplatast tosilate dry syrup (6 mg/kg daily) or a histamine H(1)-blocker (ketotifen fumarate dry syrup: 0.06 mg/kg daily) was administered randomly to 53 infants with atopic dermatitis caused by food allergies. The primary endpoints were the incidence of asthma and the time to the onset of wheezing. The peripheral blood Th1/Th2 ratio, total IgE level, and eosinophil count were measured before and after treatment. After 24 months of treatment, the prevalence of asthma was significantly lower in the suplatast group (20.8%) than in the ketotifen group (65.6%, p < 0.01). Additionally, the time from the start of treatment to the initial episode of wheezing for infants who developed asthma was significantly longer in the suplatast group than the ketotifen group (p < 0.01). Furthermore, the eosinophil count was significantly decreased by suplatast treatment (p < 0.05), and there was a significant difference between the suplatast and ketotifen groups with respect to both the eosinophil count (p < 0.01) and the Th1/Th2 ratio (p < 0.05). The results of the present pilot study suggest that suplatast tosilate is useful for the primary prevention of wheezing and asthma in children. |
| | |
Authors:
|
Shigemi Yoshihara; Mika Ono; Yumi Yamada; Hironobu Fukuda; Toshio Abe; Osamu Arisaka |
Related Documents
:
|
8285534 - Correction of prominent zygomata by tripod osteotomy of the malar bone. 10439524 - Protein contact dermatitis in food workers. case report of a meat sorter and summary of... 12075204 - The value of maximum jaw motion measurements for distinguishing between common temporom... 23372694 - Energy budget, behavior and leptin in striped hamsters subjected to food restriction an... 7702474 - Food safety and residues in australian agricultural produce. 19055024 - Feeding habits, fine structure and microhabitat preference of euthyplocia hecuba (hagen... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial Date: 2009-02-02 |
Journal Detail:
|
Title: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Volume: 20 ISSN: 1399-3038 ISO Abbreviation: Pediatr Allergy Immunol Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-08-13 Completed Date: 2009-10-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9106718 Medline TA: Pediatr Allergy Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 486-92 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan. shigemi@dokkyomed.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Allergens
/
adverse effects,
immunology Animals Anti-Allergic Agents* / administration & dosage, therapeutic use Arylsulfonates* / administration & dosage, therapeutic use Asthma / epidemiology, prevention & control* Chemoprevention Dermatitis, Atopic* / drug therapy, etiology Egg White / adverse effects Female Food Hypersensitivity* / complications, drug therapy, etiology Humans Hypersensitivity, Immediate / prevention & control* Incidence Infant Ketotifen / pharmacology, therapeutic use Male Milk / adverse effects, immunology Pilot Projects Respiratory Sounds / drug effects* Sulfonium Compounds* / administration & dosage, therapeutic use Th1 Cells / immunology Th2 Cells / immunology Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Allergens; 0/Anti-Allergic Agents; 0/Arylsulfonates; 0/Sulfonium Compounds; 34580-13-7/Ketotifen; 94055-76-2/suplatast tosilate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Does soil nitrogen influence growth, water transport and survival of snow gum (Eucalyptus pauciflora...
Next Document: Real-time PCR is more specific than conventional PCR for induced sputum diagnosis of Pneumocystis pn...