Document Detail

Early initiation of statin therapy in acute coronary syndromes: a review of the evidence.
MedLine Citation:
PMID:  15788056     Owner:  NLM     Status:  MEDLINE    
Acute coronary syndromes (ACS), such as myocardial infarction and unstable angina, are leading causes of death in developed countries. The risk of recurrent adverse events, rehospitalization, and death remain high in the weeks to months following ACS. Large secondary prevention trials have shown that the initiation of statin therapy within 3-6 months after hospitalization for ACS decreases the risk of recurrent cardiovascular events and death. Although the precise mechanisms behind these clinical benefits are unknown, data from human and animal studies have implicated statins in inflammatory response modulation, plaque stability, thrombus formation, and endothelial function. Several observational studies have demonstrated cardiovascular mortality and morbidity benefits in patients with ACS who were placed on statins within hours to days of their event. Three recent prospective controlled trials confirmed these benefits and demonstrated that moderate doses of statins are safe when used in patients with ACS. We recommend the initiation of statin therapy in all ACS patients prior to hospital discharge.
Matthew T Rondina; Joseph B Muhlestein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  18     ISSN:  0896-4327     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-24     Completed Date:  2005-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-63     Citation Subset:  IM    
Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
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MeSH Terms
Coronary Disease / drug therapy*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Prospective Studies
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

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