| Early inflammatory response to carrageenan in the pleural cavity and paw of rats with altered body temperature. | |
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MedLine Citation:
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PMID: 2880974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polymorphonuclear leucocyte (PMNL) migration and oedema induced by carrageenan in the pleural cavity and paw, respectively, of rats made hyper- or hypothermic by physical and chemical means have been investigated. In rats placed in a warm environment to produce a rise in body temperature, carrageenan caused a moderate but significant increase in PMNL migration compared with the control animals. Opposite effects were obtained with hypothermic animals kept in a cold environment. While hyperthermia produced by amphetamine did not alter the PMNL migration, chlorpromazine-induced hypothermia caused a fall in the number of these cells present in the pleural cavity following carrageenan. Both hyper- and hypothermias, whether induced by physical or chemical means, inhibited the carrageenan paw oedema. The observed changes in the PMNL numbers in the pleural cavity did not reflect their numbers in the peripheral circulation. Results indicate that while a rise or a fall in body temperature may have opposite effects on PMNL migration, in carrageenan inflammation both conditions inhibit oedema formation. |
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Authors:
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G Thomas; P S Sousa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 38 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1986 Dec |
Date Detail:
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Created Date: 1987-04-01 Completed Date: 1987-04-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 936-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphetamine
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pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology* Body Temperature* Carrageenan Chlorpromazine / pharmacology Edema / etiology, physiopathology* Male Neutrophils / drug effects Pleurisy / etiology, physiopathology* Rats Temperature Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 300-62-9/Amphetamine; 50-53-3/Chlorpromazine; 9000-07-1/Carrageenan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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