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Early inflammatory cytokine response: A direct comparison between spontaneous coronary plaque destabilization vs angioplasty induced.
MedLine Citation:
PMID:  25173071     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: To compare inflammatory response accompanying acute coronary syndrome (ACS) with that following coronary plaque rupture caused by coronary angioplasty (PCI).
METHODS: Twenty-seven consecutive subjects with either ACS or treated with PCI in the subacute phase of ACS underwent serial evaluation of circulating interleukin (IL)-2, IL-8, IL-10, interferon (IFN)-γ and tumor-necrosis-factor (TNF)-α levels. Blood samples were drawn immediately before angioplasty (T0) in the PCI group or at admission in the ACS group, 12 h (T1) and 24 h later (T2).
RESULTS: Differences between cytokine levels were substantially not statistically significant when comparing PCI, non-ST-elevation-ACS, and ST-elevation-ACS groups, especially 24 h after plaque rupture (T2, Type-II error 85-94%).
CONCLUSIONS: Inflammatory activation during the first 24 h of ACS or after PCI is comparable, regardless of myocardial damage in terms of troponin levels. Coronary plaque rupture may be presumed as being the main responsible for increased circulating cytokine levels in this early phase.
Authors:
Natale Daniele Brunetti; Michele Correale; Pier Luigi Pellegrino; Irene Munno; Andrea Cuculo; Luisa De Gennaro; Antonio Gaglione; Matteo Di Biase
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-15
Journal Detail:
Title:  Atherosclerosis     Volume:  236     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  456-460     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
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