Document Detail


Early inflammation and risk of long-term development of heart failure and mortality in survivors of acute myocardial infarction predictive role of C-reactive protein.
MedLine Citation:
PMID:  16516078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We aimed to study the relationship between C-reactive-protein (CRP), obtained within 12 to 24 h of symptoms onset, and long-term risk of death and heart failure (HF) in survivors of acute myocardial infarction (MI). BACKGROUND: A robust inflammatory response is an integral component of the response to tissue injury during MI. The magnitude of the early inflammatory response to ischemic injury might be an important determinant of long-term outcome. METHODS: We prospectively studied 1,044 patients admitted with acute MI and discharged from hospital in stable condition. RESULTS: During a median follow-up of 23 months (range, 6 to 42 months), 113 patients died and 112 developed HF. In a multivariable Cox regression model adjusting for clinical variables and predischarge ejection fraction, compared with patients in the first CRP quartile, the adjusted hazard ratios (HRs) for death progressively increased with higher quartiles of CRP (second quartile 1.4 [95% confidence interval (CI) 0.6 to 2.9]; third quartile 2.3 [95% CI 1.2 to 4.6]; fourth quartile 3.0 [95% CI 1.5 to 5.7]; for trend, p = 0.0002). Compared with patients in the first CRP quartile, the adjusted HRs for HF were: second quartile, 1.1 (95% CI 0.5 to 2.3); third quartile, 1.9 (95% CI 1.0 to 3.6); and fourth quartile, 2.1 (95% CI 1.2 to 3.9) (for trend, p = 0.005). CONCLUSIONS: C-reactive-protein is a marker of long-term development of HF and mortality in patients with acute MI and provides prognostic information beyond that provided by conventional risk factors and the degree of left ventricular systolic dysfunction.
Authors:
Mahmoud Suleiman; Rania Khatib; Yoram Agmon; Riad Mahamid; Monther Boulos; Michael Kapeliovich; Yishai Levy; Rafael Beyar; Walter Markiewicz; Haim Hammerman; Doron Aronson
Related Documents :
19064008 - Magnitude and prognosis associated with ventricular arrhythmias in patients hospitalize...
15904648 - Association of height with outcomes in patients with acute myocardial infarction receiv...
17161068 - Predictors of death or myocardial infarction during follow-up after coronary stenting w...
11888508 - Elevated levels of plasma prekallikrein, high molecular weight kininogen and factor xi ...
7628028 - Detection of intraoperative myocardial ischaemia--a comparison among electrocardiograph...
2093368 - Perioperative assessment of the quality of myocardial protection.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  47     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-05-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  962-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, Rambam Medical Center and the Bruce Rappaport faculty of medicine, Haifa, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
C-Reactive Protein / analysis*
Female
Heart Failure / etiology*,  mortality*
Humans
Inflammation / etiology*
Male
Middle Aged
Myocardial Infarction / blood*,  complications,  mortality*
Prospective Studies
Risk Factors
Survivors
Time Factors
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prognostic implications of creatine kinase elevation after primary percutaneous coronary interventio...
Next Document:  Patients with hibernating myocardium show altered left ventricular volumes and shape, which revert a...