Document Detail

Early inflammation in the absence of overt infection in preterm neonates exposed to intensive care.
MedLine Citation:
PMID:  21940177     Owner:  NLM     Status:  Publisher    
BACKGROUND: Systemic inflammation, typically attributed to sepsis, has been repeatedly linked to adverse long-term outcomes in infants born prematurely. However, it is unclear whether other factors can contribute to potentially harmful systemic inflammatory responses. OBJECTIVE: To determine the timing and extent of systemic inflammation occurring in absence of infection in preterm infants exposed to intensive care. METHODS: First, we screened for inflammation biomarkers most strongly linked to infection in a large prospective cohort of 425 newborns (gestational age 24-42weeks). Second, we longitudinally measured levels of infection-related inflammation biomarkers up to 42days of post-natal life in a series of 58 infants born ⩽30weeks of gestation exposed to intensive care. Ante- or post-natal infections were excluded using stringent definitions including rigorous histological placental examination. Spearman correlations were used to identify putative clinical factors potentially linked to inflammation. RESULTS: Three biomarkers were most strongly associated with neonatal sepsis (IL-6, IL-8 and G-CSF) in the first cohort. Using these markers, we found a predominant early high intensity systemic inflammation period within the first 72h of preterm infants' extra-uterine life. Remarkably, this systemic inflammatory response was of magnitude comparable to that observed during sepsis in absence of ante- or post-natal signs of infection, and correlated with the amount of supplemental oxygen exposure (r=0.51-0.60). CONCLUSIONS: Non-infectious sources of systemic inflammation are significant in preterm infants exposed to intensive care and may contribute to intensive care-related organ injury.
Brent A Chang; Qing Huang; Joanne Quan; Vann Chau; Mihoko Ladd; Eddie Kwan; Deborah E McFadden; Thierry Lacaze-Masmonteil; Steven P Miller; Pascal M Lavoie
Related Documents :
11271397 - Prophylaxis of intravenous immunoglobulin and acyclovir in perinatal varicella.
9767217 - Practices that minimize trauma to the genital tract in childbirth: a systematic review ...
21212697 - Severe neonatal hyperbilirubinemia and adverse short-term consequences in baghdad, iraq.
21345707 - Exposure to trimethoprim/sulfamethoxazole but not other fda category c and d anti-infec...
1604977 - The ontogeny of human hearing.
18207437 - Fecal microflora of greek healthy neonates.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-20
Journal Detail:
Title:  Cytokine     Volume:  -     ISSN:  1096-0023     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Child & Family Research Institute, University of British Columbia, Vancouver, Canada; Department of Pediatrics, University of British Columbia, Vancouver, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  FTIR and circular dichroism spectroscopic study of interaction of 5-fluorouracil with DNA.
Next Document:  Monitoring serum levels ELR(+) CXC chemokines and the relationship between microvessel density and a...