Document Detail


Early infectious complications with transponder placement for external beam radiation therapy for prostate cancer.
MedLine Citation:
PMID:  22925704     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: •  To report our series of early infectious complications after placement of Calypso® transponders (Calypso Medical, Seattle, WA, USA) into the prostate.
PATIENTS AND METHODS: •  Between February 2008 and October 2010, 50 consecutive patients underwent placement of Calypso® transponders into the prostate. •  Patients were administered ciprofloxacin 500 mg every 12 h, starting the night before the procedure and for 2 days after the procedure. •  Data were collected via chart review, and complications were classified according to the Clavien classification system.
RESULTS: •  Of the 50 patients undergoing the procedure, five (10%) developed infectious complications, and three (6%) developed a grade II complication with a UTI requiring antibiotic therapy. One patient (2%) developed a grade IIIb complication with an epidural abscess and osteomyelitis of the lumbar vertebrae requiring open debridement and a lumbar fusion. One patient (2%) developed a prostatic abscess with methicillin-resistant Staphylococcus aureus and subsequently died of an unrelated lower GI bleed. •  In 4/50 patients (8%), a culture confirmed the responsible bacteria, of which three cases were quinolone-resistant Escherichia coli.
CONCLUSION: •  As with prostate biopsy, the emergence of quinolone-resistant E. coli remains a challenging infectious complication with transrectal prostate procedures. We propose an alternative strategy of double antibiotic coverage with one dose of oral ciprofloxacin 500 mg and gentamicin 80 mg i.m. before this procedure.
Authors:
Ryan K Berglund; Osama Zaytoun; Richard Thousand; Kevin Stephans; Rahul Tendulkar; Eric A Klein; J Stephen Jones
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Publication Detail:
Type:  Journal Article     Date:  2012-02-16
Journal Detail:
Title:  BJU international     Volume:  110     ISSN:  1464-410X     ISO Abbreviation:  BJU Int.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  834-8     Citation Subset:  IM    
Copyright Information:
© 2012 BJU INTERNATIONAL.
Affiliation:
Glickman Urologic and Kidney Insititute, and Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA.
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